Protein basic information
| LiverAtlas Protein ID |
HuLPr25379 |
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Uniprot ID |
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Uniprot Acc |
P46940;A7MBM3; |
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Protein name |
Ras GTPase-activating-like protein IQGAP1 |
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Comment |
FUNCTION:Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth.||SUBUNIT:Interacts with CDC42; the interaction is demonstrated with IQGAP1 in GTP-bound and in nucleotide-free state. Interacts with RAC1. Does not interact with RHOA. Interacts with TSG101.||INTERACTION:P62330:ARF6; NbExp=1; IntAct=EBI-297509, EBI-638181; P60953:CDC42; NbExp=2; IntAct=EBI-297509, EBI-81752;||SUBCELLULAR LOCATION:Cell membrane.||TISSUE SPECIFICITY:Expressed in the placenta, lung, and kidney. A lower level expression is seen in the heart, liver, skeletal muscle and pancreas.||DOMAIN:Regions C1 and C2 can either interact with nucleotide-free CDC42, or interact together, depending on the phosphorylation state of Ser-1443. When Ser-1443 is not |
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Subcellular localization |
Cell membrane. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVA YEYLCHLEEAKRWMEACLGEDLPPTTELEEGLRNGVYLA KLGNFFSPKVVSLKKIYDREQTRYKATGLHFRHTDNVIQ WLNAMDEIGLPKIFYPETTDIYDRKNMPRCIYCIHALSL YLFKLGLAPQIQDLYGKVDFTEEEINNMKTELEKYGIQM PAFSKIGGILANELSVDEAALHAAVIAINEAIDRRIPAD TFAALKNPNAMLVNLEEPLASTYQDILYQAKQDKMTNAK NRTENSERERDVYEELLTQAEIQGNINKVNTFSALANID LALEQGDALALFRALQSPALGLRGLQQQNSDWYLKQLLS DKQQKRQSGQTDPLQKEELQSGVDAANSAAQQYQRRLAA VALINAAIQKGVAEKTVLELMNPEAQLPQVYPFAADLYQ KELATLQRQSPEHNLTHPELSVAVEMLSSVALINRALES GDVNTVWKQLSSSVTGLTNIEEENCQRYLDELMKLKAQA HAENNEFITWNDIQACVDHVNLVVQEEHERILAIGLINE ALDEGDAQKTLQALQIPAAKLEGVLAEVAQHYQDTLIRA KREKAQEIQDESAVLWLDEIQGGIWQSNKDTQEAQKFAL GIFAINEAVESGDVGKTLSALRSPDVGLYGVIPECGETY HSDLAEAKKKKLAVGDNNSKWVKHWVKGGYYYYHNLETQ EGGWDEPPNFVQNSMQLSREEIQSSISGVTAAYNREQLW LANEGLITRLQARCRGYLVRQEFRSRMNFLKKQIPAITC IQSQWRGYKQKKAYQDRLAYLRSHKDEVVKIQSLARMHQ ARKRYRDRLQYFRDHINDIIKIQAFIRANKARDDYKTLI NAEDPPMVVVRKFVHLLDQSDQDFQEELDLMKMREEVIT LIRSNQQLENDLNLMDIKIGLLVKNKITLQDVVSHSKKL TKKNKEQLSDMMMINKQKGGLKALSKEKREKLEAYQHLF YLLQTNPTYLAKLIFQMPQNKSTK |
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Database cross reference |
RefSeq Protein accession:NP_003861
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005884;C:actin filament;TAS:ProtInc. GO:0005737;C:cytoplasm;IDA:HPA. GO:0030496;C:midbody;IDA:UniProtKB. GO:0005634;C:nucleus;IDA:HPA. GO:0005886;C:plasma membrane;IDA:HPA. |
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GO-F |
GO:0005516;F:calmodulin binding;TAS:ProtInc. GO:0005095;F:GTPase inhibitor activity;TAS:ProtInc. GO:0019903;F:protein phosphatase binding;IPI:UniProtKB. GO:0005099;F:Ras GTPase activator activity;IEA:InterPro. |
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GO-P |
GO:0006112;P:energy reserve metabolic proces |