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Protein basic information

LiverAtlas Protein ID

HuLPr25381

Uniprot ID

IQGA3_HUMAN

Uniprot Acc

Q86VI3;Q5T3H8;

Protein name

Ras GTPase-activating-like protein IQGAP3

Comment

SIMILARITY:Contains 1 CH (calponin-homology) domain.||SIMILARITY:Contains 4 IQ domains.||SIMILARITY:Contains 1 Ras-GAP domain.

Gene name

IQ motif containing GTPase activating protein 3

Protein sequence

MERRAAGPGWAAYERLTAEEMDEQRRQNVAYQYLCRLEEA KRWMEACLKEELPSPVELEESLRNGVLLAKLGHCFAPSV VPLKKIYDVEQLRYQATGLHFRHTDNINFWLSAIAHIGL PSTFFPETTDIYDKKNMPRVVYCIHALSLFLFRLGLAPQ IHDLYGKVKFTAEELSNMASELAKYGLQLPAFSKIGGIL ANELSVDEAAVHAAVLAINEAVERGVVEDTLAALQNPSA LLENLREPLAAVYQEMLAQAKMEKAANARNHDDRESQDI YDHYLTQAEIQGNINHVNVHGALEVVDDALERQSPEALL KALQDPALALRGVRRDFADWYLEQLNSDREQKAQELGLV ELLEKEEVQAGVAAANTKGDQEQAMLHAVQRINKAIRRR VAADTVKELMCPEAQLPPVYPVASSMYQLELAVLQQQQG ELGQEELFVAVEMLSAVVLINRALEARDASGFWSSLVNP ATGLAEVEGENAQRYFDALLKLRQERGMGEDFLSWNDLQ ATVSQVNAQTQEETDRVLAVSLINEALDKGSPEKTLSAL LLPAAGLDDVSLPVAPRYHLLLVAAKRQKAQVTGDPGAV LWLEEIRQGVVRANQDTNTAQRMALGVAAINQAIKEGKA AQTERVLRNPAVALRGVVPDCANGYQRALESAMAKKQRP ADTAFWVQHDMKDGTAYYFHLQTFQGIWEQPPGCPLNTS HLTREEIQSAVTKVTAAYDRQQLWKANVGFVIQLQARLR GFLVRQKFAEHSHFLRTWLPAVIKIQAHWRGYRQRKIYL EWLQYFKANLDAIIKIQAWARMWAARRQYLRRLHYFQKN VNSIVKIQAFFRARKAQDDYRILVHAPHPPLSVVRRFAH LLNQSQQDFLAEAELLKLQEEVVRKIRSNQQLEQDLNIM DIKIGLLVKNRITLQEVVSHCKKLTKRNKEQLSDMMVLD KQKGLKSLSKEKRQKLEAYQHLFYLLQTQPIYLAKLIFQ MPQNKTTKFMEAVIFSLYNYASSR

Database cross reference

RefSeq Protein accession:NP_839943
RefSeq Protein gi:39753961

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005622;C:intracellular;IEA:InterPro.

GO-F

GO:0005516;F:calmodulin binding;IEA:UniProtKB-KW. GO:0005099;F:Ras GTPase activator activity;IEA:InterPro.

GO-P

GO:0007264;P:small GTPase mediated signal transduction;IEA:InterPro.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr25381

PHOSPHORYLATION

1424

S

Phospho-ELM

36814

HTP

N

HuLPr25381

PHOSPHORYLATION

1537

Y

Phospho-ELM

21944

HTP

N

HuLPr25381

PHOSPHORYLATION

1098

Y

PhosphoSitePlus

12000519

LTP

N

HuLPr25381

ACETYLATION

938

K

PhosphoSitePlus

9833031

LTP

N

HuLPr25381

PHOSPHORYLATION

1415

T

PhosphoSitePlus

4274197

LTP

N

HuLPr25381

PHOSPHORYLATION

1424

S

PhosphoSitePlus

3204825

LTP

N

HuLPr25381

PHOSPHORYLATION

539

S

PhosphoSitePlus

4274920

LTP

N

HuLPr25381

PHOSPHORYLATION

1268

Y

PhosphoSitePlus

473505

LTP

N

HuLPr25381

PHOSPHORYLATION

1360

S

PhosphoSitePlus

14567563

HTP

N

HuLPr25381

PHOSPHORYLATION

1362

T

PhosphoSitePlus

14567566

LTP

N

HuLPr25381

PHOSPHORYLATION

1537

Y

PhosphoSitePlus

1038573

LTP

HTP

N

Pathway

Pathway name

CDC42_signaling_events

Pathway name

RAC1_signaling_pathway