HuLPr25409

Uniprot ID

IRK5_HUMAN

Uniprot Acc

P48544;B2R744;Q6DK13;Q6DK14;Q92807;

Protein name

G protein-activated inward rectifier potassium channel 4

Comment

FUNCTION:This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium.||SUBUNIT:May associate with GIRK1 and GIRK2 to form a G-protein- activated heteromultimer pore-forming unit. The resulting inward current is much larger (By similarity).||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Islets, exocrine pancreas and heart.||DISEASE:Defects in KCNJ5 are the cause of long QT syndrome type 13 (LQT13) [MIM:613485]. It is a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ven

Subcellular localization

Membrane;Multi-pass membrane protein.

Gene name

potassium inwardly-rectifying channel, subfamily J, member 5

Protein sequence

MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRT RLLAEGKKPRQRYMEKSGKCNVHHGNVQETYRYLSDLFT TLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDL DHVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVI TEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKR AETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIR AKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPL IISHEINQKSPFWEMSQAQLHQEEFEVVVILEGMVEATG MTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFH DTYETNTPSCCAKELAEMKREGRLLQYLPSPPLLGGCAE AGLDAEAEQNEEDEPKGLGGSREARGSV

Database cross reference

RefSeq Protein accession:NP_000881
RefSeq Protein gi:24797141

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0008076;C:voltage-gated potassium channel complex;TAS:ProtInc.

GO-F

GO:0015467;F:G-protein activated inward rectifier potassium channel activity;TAS:UniProtKB. GO:0005515;F:protein binding;IPI:BHF-UCL.

GO-P

GO:0007268;P:synaptic transmission;TAS:Reactome.