HuLPr25480

Uniprot ID

ITIH5_HUMAN

Uniprot Acc

Q86UX2;Q5T664;Q5T665;Q5T666;Q6AI60;Q6UXB7;Q8TF48;Q8WYV2;Q96K70;

Protein name

Inter-alpha-trypsin inhibitor heavy chain H5

Comment

FUNCTION:May act as a tumor suppressor.||SUBCELLULAR LOCATION:Secreted (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q86UX2-1; Sequence=Displayed; Name=2; IsoId=Q86UX2-2; Sequence=VSP 033190, VSP 033191; Name=3; IsoId=Q86UX2-3; Sequence=VSP 033188, VSP 033189; Name=4; IsoId=Q86UX2-4; Sequence=VSP 035727, VSP 035728, VSP 035729, VSP 035730; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Abundantly expressed in placenta. Less abundant expression in mammary gland and ovary. Expression is barely detectable levels in all other tissues tested.||INDUCTION:Down-regulated in breast tumors.||SIMILARITY:Belongs to the ITIH family.||SIMILARITY:Contains 1 VIT domain.||SIMILARITY:Contains 1 VWFA domain.||CAUTION:Conflict in position 933 in the human genome assembly due to a frameshift.||SEQUENCE CAUTION:Sequence=CAI12953.1; Type=Frameshift; Positions=933; Sequence=CAI12955.1; Type=Frameshift;

Subcellular localization

Secreted(By similarity).

Gene name

inter-alpha (globulin) inhibitor H5

Protein sequence

MLLLLGLCLGLSLCVGSQEEAQSWGHSSEQDGLRVPRQVR LLQRLKTKPLMTEFSVKSTIISRYAFTTVSCRMLNRASE DQDIEFQMQIPAAAFITNFTMLIGDKVYQGEITEREKKS GDRVKEKRNKTTEENGEKGTEIFRASAVIPSKDKAAFFL SYEELLQRRLGKYEHSISVRPQQLSGRLSVDVNILESAG IASLEVLPLHNSRQRGSGRGEDDSGPPPSTVINQNETFA NIIFKPTVVQQARIAQNGILGDFIIRYDVNREQSIGDIQ VLNGYFVHYFAPKDLPPLPKNVVFVLDSSASMVGTKLRQ TKDALFTILHDLRPQDRFSIIGFSNRIKVWKDHLISVTP DSIRDGKVYIHHMSPTGGTDINGALQRAIRLLNKYVAHS GIGDRSVSLIVFLTDGKPTVGETHTLKILNNTREAARGQ VCIFTIGIGNDVDFRLLEKLSLENCGLTRRVHEEEDAGS QLIGFYDEIRTPLLSDIRIDYPPSSVVQATKTLFPNYFN GSEIIIAGKLVDRKLDHLHVEVTASNSKKFIILKTDVPV RPQKAGKDVTGSPRPGGDGEGDTNHIERLWSYLTTKELL SSWLQSDDEPEKERLRQRAQALAVSYRFLTPFTSMKLRG PVPRMDGLEEAHGMSAAMGPEPVVQSVRGAGTQPGPLLK KPYQPRIKISKTSVDGDPHFVVDFPLSRLTVCFNIDGQP GDILRLVSDHRDSGVTVNGELIGAPAPPNGHKKQRTYLR TITILINKPERSYLEITPSRVILDGGDRLVLPCNQSVVV GSWGLEVSVSANANVTVTIQGSIAFVILIHLYKKPAPFQ RHHLGFYIANSEGLSSNCHGLLGQFLNQDARLTEDPAGP SQNLTHPLLLQVGEGPEAVLTVKGHQVPVVWKQRKIYNG EEQIDCWFARNNAAKLIDGEYKDYLAFHPFDTGMTLGQGMSREL

Database cross reference

RefSeq Protein accession:NP_001001851
RefSeq Protein gi:49355778

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell.

GO-F

GO:0004867;F:serine-type endopeptidase inhibitor activity;IEA:UniProtKB-KW.

GO-P

GO:0030212;P:hyaluronan metabolic process;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr25480

PHOSPHORYLATION

743

T

PhosphoSitePlus

485118

LTP

N