Protein basic information
| LiverAtlas Protein ID |
HuLPr25503 |
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Uniprot ID |
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Uniprot Acc |
P78504;A0AV43;O14902;O15122;Q15816; |
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Protein name |
Protein jagged-1 |
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Comment |
FUNCTION:Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).||SUBUNIT:Interacts with NOTCH1, NOTCH2 and NOTCH3 (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein.||TISSUE SPECIFICITY:Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.||DEVELOPMENTAL STAGE:Expressed in 32-52 days embryos in the distal cardiac outflow tract and pulmonary artery, major arteries, portal vein, optic vesicle, otoc |
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Subcellular localization |
Membrane;Single-pass type I membrane protein. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEIL SMQNVNGELQNGNCCGGARNPGDRKCTRDECDTYFKVCL KEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRN RIVLPFSFAWPRSYTLLVEAWDSSNDTVQPDSIIEKASH SGMINPSRQWQTLKQNTGVAHFEYQIRVTCDDYYYGFGC NKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICR QGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHG ICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCS NTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCK ETSLGFECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQD LVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNL IASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVN GYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINR FQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDY FCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASND TPEGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTY CHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYC ETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCH SRDSQCDEATCNNGGTCYDEGDAFKCMCPGGWEGTTCNI ARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQ NTNDCSPHPCYNSGTCVDGDNWYRCECAPGFAGPDCRIN INECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVS GRPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCG PRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGECR SSSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSPGLTT EHICSELRNLNILKNVSAEYSIYI |
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Database cross reference |
RefSeq Protein accession:NP_000205
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005576;C:extracellular region;NAS:UniProtKB. GO:0005887;C:integral to plasma membrane;NAS:UniProtKB. |
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GO-F |
GO:0005509;F:calcium ion binding;NAS:UniProtKB. GO:0008083;F:growth factor activity;NAS:UniProtKB. GO:0005112;F:Notch binding;NAS:UniProtKB. GO:0005198;F:structural molecule activity;NAS:UniProtKB. |
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GO-P |
GO:0001525;P:angiogenesis;NAS:UniProtKB. GO:0007154;P:cell communication;IEA:InterPro. GO:0001709;P:cell fate determination;NAS:UniProtKB. GO:0045446;P:endothelial cell diff |