Protein basic information
| LiverAtlas Protein ID |
HuLPr25661 |
|
Uniprot ID |
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Uniprot Acc |
P48668;A1L4L5;P48666;Q2TAZ9;Q7RTN9; |
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Protein name |
Keratin, type II cytoskeletal 6C |
|
Comment |
SUBUNIT:Heterodimer of a type I and a type II keratin. KRT6 isomers associate with KRT16 and/or KRT17.||TISSUE SPECIFICITY:Constitutively expressed in distinct types of epithelia such as those in oral mucosa, esophagus, papillae of tongue and hair follicle outer root sheath.||MISCELLANEOUS:There are at least six isoforms of human type II keratin-6 (K6).||MISCELLANEOUS:There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40- 55 and 56-70 kDa, respectively).||SIMILARITY:Belongs to the intermediate filament family. |
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Gene name |
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Protein sequence
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MASTSTTIRSHSSSRRGFSANSARLPGVSRSGFSSISVSR SRGSGGLGGACGGAGFGSRSLYGLGGSKRISIGGGSCAI SGGYGSRAGGSYGFGGAGSGFGFGGGAGIGFGLGGGAGL AGGFGGPGFPVCPPGGIQEVTVNQSLLTPLNLQIDPAIQ RVRAEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWT LLQEQGTKTVRQNLEPLFEQYINNLRRQLDSIVGERGRL DSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDV DAAYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHI SDTSVVLSMDNNRNLDLDSIIAEVKAQYEEIAQRSRAEA ESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRL RSEIDHVKKQCASLQAAIADAEQRGEMALKDAKNKLEGL EDALQKAKQDLARLLKEYQELMNVKLALDVEIATYRKLL EGEECRLNGEGVGQVNVSVVQSTISSGYGGASGVGSGLG LGGGSSYSYGSGLGIGGGFSSSSGRAIGGGLSSVGGGSS TIKYTTTSSSSRKSYKH |
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Database cross reference |
RefSeq Protein accession:NP_775109
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver; |
Ontology annotation
| GO-C |
GO:0045095;C:keratin filament;IEA:InterPro. |
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GO-F |
GO:0005198;F:structural molecule activity;NAS:UniProtKB. |
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GO-P |
GO:0007010;P:cytoskeleton organization;NAS:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr25661 |
PHOSPHORYLATION |
60 |
S |
Phospho-ELM |
LTP |
N |
 
|
|
|
HuLPr25661 |
PHOSPHORYLATION |
341 |
Y |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr25661 |
PHOSPHORYLATION |
62 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25661 |
PHOSPHORYLATION |
83 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25661 |
PHOSPHORYLATION |
60 |
S |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr25661 |
SUMOYLATION |
173 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25661 |
PHOSPHORYLATION |
356 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25661 |
PHOSPHORYLATION |
360 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25661 |
PHOSPHORYLATION |
551 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25661 |
ACETYLATION |
180 |
K |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25661 |
PHOSPHORYLATION |
278 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25661 |
PHOSPHORYLATION |
176 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25661 |
ACETYLATION |
173 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr25661 |
PHOSPHORYLATION |
341 |
Y |
PhosphoSitePlus |
LTP |
N |
|
