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Protein basic information

LiverAtlas Protein ID

HuLPr25821

Uniprot ID

KCNS1_HUMAN

Uniprot Acc

Q96KK3;A2RUL9;B7ZM31;O43652;Q6DJU6;

Protein name

Potassium voltage-gated channel subfamily S member 1

Comment

FUNCTION:Potassium channel subunit. Modulates channel activity and reduces the ion flow (By similarity).||SUBUNIT:Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins (By similarity).||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.||TISSUE SPECIFICITY:Detected in all tissues tested with the exception of skeletal muscle. Highly expressed in adult and fetal brain, fetal kidney and lung, and adult prostate and testis.||DOMAIN:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.||SIMILARITY:Belongs to the potassium channel family. S (TC 1.A.1.2) subfamily. Kv9.1/KCNS1 sub-subfamily.

Subcellular localization

Cell membrane;Multi-pass membrane protein.

Gene name

potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1

Protein sequence

MLMLLVRGTHYENLRSKVVLPTPLGGRSTETFVSEFPGPD TGIRWRRSDEALRVNVGGVRRQLSARALARFPGTRLGRL QAAASEEQARRLCDDYDEAAREFYFDRHPGFFLSLLHFY RTGHLHVLDELCVFAFGQEADYWGLGENALAACCRARYL ERRLTQPHAWDEDSDTPSSVDPCPDEISDVQRELARYGA ARCGRLRRRLWLTMENPGYSLPSKLFSCVSISVVLASIA AMCIHSLPEYQAREAAAAVAAVAAGRSPEGVRDDPVLRR LEYFCIAWFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSV LPFYLTLLAGVALGDQGGKEFGHLGKVVQVFRLMRIFRV LKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFS GVAYTAEKEEDVGFNTIPACWWWGTVSMTTVGYGDVVPV TVAGKLAASGCILGGILVVALPITIIFNKFSHFYRRQKA LEAAVRNSNHQEFEDLLSSIDGVSEASLETSRETSQEGQ SADLESQAPSEPPHPQMY

Database cross reference

RefSeq Protein accession:NP_002242
RefSeq Protein gi:13492973

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0008076;C:voltage-gated potassium channel complex;IDA:UniProtKB.

GO-F

GO:0005251;F:delayed rectifier potassium channel activity;IDA:UniProtKB. GO:0015459;F:potassium channel regulator activity;IDA:UniProtKB. GO:0005515;F:protein binding;IPI:UniProtKB.