Protein basic information
| LiverAtlas Protein ID |
HuLPr25848 |
|
Uniprot ID |
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Uniprot Acc |
O60341;A8MWP9;Q5TH94;Q5TH95;Q86VT7;Q8IXK4;Q8NDP6;Q8TAZ3;Q96AW4; |
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Protein name |
Lysine-specific histone demethylase 1A |
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Comment |
FUNCTION:Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr- 6' of histone H3 (H3T6ph), a specifi |
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Subcellular localization |
Nucleus. |
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Gene name |
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Protein sequence
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MLSGKKAAAAAAAAAAAATGTEAGPGTAGGSENGSEVAAQ PAGLSGPAEVGPGAVGERTPRKKEPPRASPPGGLAEPPG SAGPQAGPTVVPGSATPMETGIAETPEGRRTSRRKRAKV EYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQ APPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACF PDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATL QQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLP TKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRV GGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNME LAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSY LSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEH WKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVK PPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKL QELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTL SLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKL NTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTL PLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVL CFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPIL LALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQ PKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPIT PGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLR EAGRIADQFLGAMYTLPRQATPGVPAQQSPSM |
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Database cross reference |
RefSeq Protein accession:NP_001009999
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0000790;C:nuclear chromatin;IDA:BHF-UCL. |
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GO-F |
GO:0050681;F:androgen receptor binding;IDA:UniProtKB. GO:0003682;F:chromatin binding;IDA:UniProtKB. GO:0019899;F:enzyme binding;IPI:BHF-UCL. GO:0050660;F:flavin adenine dinucleotide binding;IDA:UniProtKB. GO:0034648;F:histone demethylase activity (H3-d |
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GO-P |
GO:0007596;P:blood coagulation;TAS:Reactome. GO:0055001;P:muscle cell development;ISS:BHF-UCL. GO:0010553;P:negative regulation of gene-specific transcription from RNA polymerase II promoter;ISS:BHF-UCL. GO:0043433;P:negative regulation of sequence-spec |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr25848 |
PHOSPHORYLATION |
104 |
T |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
126 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
135 |
Y |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
136 |
Y |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
59 |
T |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
80 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
849 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
131 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
137 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
166 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
104 |
T |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
131 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
166 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
851 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
137 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
135 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
136 |
Y |
PhosphoSitePlus |
LTP HTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
841 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
363 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
126 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
80 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
849 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25848 |
PHOSPHORYLATION |
59 |
T |
PhosphoSitePlus |
HTP |
N |
|
Pathway
| Pathway name | |
| Pathway name | |
| Pathway name |
