HuLPr25864

Uniprot ID

KDM7_HUMAN

Uniprot Acc

Q6ZMT4;A4D1S9;C9JJH9;C9JQU2;Q6MZL8;Q9C0E5;

Protein name

Lysine-specific demethylase 7

Comment

FUNCTION:Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9' and 'Lys-27' (H3K9me2 and H3K27me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity:in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate.||COFACTOR:Binds 1 Fe(2+) ion per subunit.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=1.2 uM for histone H3 H3K9Me2;||SUBCELLULAR LOCATION:Nucleus.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q6ZMT4-1; Sequence=Displayed; Name=2; IsoId=Q6ZMT4-2; Sequence=VSP 017458, VSP 017459

Subcellular localization

Nucleus.

Gene name

jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)

Protein sequence

MAGAAAAVAAGAAAGAAAAAVSVAAPGRASAPPPPPPVYC VCRQPYDVNRFMIECDICKDWFHGSCVGVEEHHAVDIDL YHCPNCAVLHGSSLMKKRRNWHRHDYTEIDDGSKPVQAG TRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFD VPIMVPKLDDLGLRLPSPTFSVMDVERYVGGDKVIDVID VARQADSKMTLHNYVKYFMNPNRPKVLNVISLEFSDTKM SELVEVPDIAKKLSWVENYWPDDSVFPKPFVQKYCLMGV QDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLAR YESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGW IHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTP DLFKFPFFEAICWFVAKNLLETLKELREDGFQPQTYLVQ GVKALHTALKLWMKKELVSEHAFEIPDNVRPGHLIKELS KVIRAIEEENGKPVKSQGIPIVCPVSRSSNEATSPYHSR RKMRKLRDHNVRTPSNLDILELHTREVLKRLEMCPWEED ILSSKLNGKFNKHLQPSSTVPEWRAKDNDLRLLLTNGRI IKDERQPFADQSLYTADSENEEDKRRTKKAKMKIEESSG VEGVEHEESQKPLNGFFTRVKSELRSRSSGYSDISESED SGPECTALKSIFTTEESESSGDEKKQEITSNFKEESNVM RNFLQKSQKPSRSEIPIKRECPTSTSTEEEAIQGMLSMA GLHYSTCLQRQIQSTDCSGERNSLQDPSSCHGSNHEVRQ LYRYDKPVECGYHVKTEDPDLRTSSWIKQFDTSRFHPQD LSRSQKCIRKEGSSEISQRVQSRNYVDSSGSSLQNGKYM QNSNLTSGACQISNGSLSPERPVGETSFSVPLHPTKRPA SNPPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHARFFV

Database cross reference

RefSeq Protein accession:NP_085150
RefSeq Protein gi:90093355

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005730;C:nucleolus;IDA:HPA.

GO-F

GO:0071558;F:histone demethylase activity (H3-K27 specific);IDA:UniProtKB. GO:0051864;F:histone demethylase activity (H3-K36 specific);IDA:UniProtKB. GO:0032454;F:histone demethylase activity (H3-K9 specific);IDA:UniProtKB. GO:0035575;F:histone demethyl

GO-P

GO:0030901;P:midbrain development;ISS:UniProtKB. GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW. GO:0006351;P:transcription, DNA-dependent;IEA:UniProtKB-KW.