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Protein basic information

LiverAtlas Protein ID

HuLPr25894

Uniprot ID

KI2LA_HUMAN

Uniprot Acc

Q8N109;

Protein name

Killer cell immunoglobulin-like receptor 2DL5A

Comment

FUNCTION:Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type I membrane protein.||SIMILARITY:Belongs to the immunoglobulin superfamily.||SIMILARITY:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Subcellular localization

Cell membrane;Single-pass type I membrane protein.

Gene name

killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A

Protein sequence

MSLMVISMACVGFFLLQGAWTHEGGQDKPLLSAWPSAVVP RGGHVTLLCRSRLGFTIFSLYKEDGVPVPELYNKIFWKS ILMGPVTPAHAGTYRCRGSHPRSPIEWSAPSNPLVIVVT GLFGKPSLSAQPGPTVRTGENVTLSCSSRSSFDMYHLSR EGRAHEPRLPAVPSVNGTFQADFPLGPATHGGTYTCFGS LHDSPYEWSDPSDPLLVSVTGNSSSSSSSPTEPSSKTGI RRHLHILIGTSVAIILFIILFFFLLHCCCSNKKNAAVMD QEPAGDRTVNREDSDDQDPQEVTYAQLDHCVFTQTKITS PSQRPKTPPTDTTMYMELPNAKPRSLSPAHKHHSQALRG SSRETTALSQNRVASSHVPAAGI

Database cross reference

RefSeq Protein accession:NP_065396
RefSeq Protein gi:11968154

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0004872;F:receptor activity;IEA:UniProtKB-KW.