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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr25896

Uniprot ID

KI2S3_HUMAN

Uniprot Acc

Q14952;O00644;

Protein name

Killer cell immunoglobulin-like receptor 2DS3

Comment

FUNCTION:Receptor on natural killer (NK) cells for HLA-C alleles. Does not inhibit the activity of NK cells.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type I membrane protein.||SIMILARITY:Belongs to the immunoglobulin superfamily.||SIMILARITY:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Subcellular localization

Cell membrane;Single-pass type I membrane protein.

Gene name

killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3

Protein sequence

MSLMVISMACVGFFWLQGAWPHEGFRRKPSLLAHPGRLVK SEETVILQCWSDVMFEHFLLHREGTFNDTLRLIGEHIDG VSKANFSIGRMRQDLAGTYRCYGSVPHSPYQFSAPSDPL DIVITGLYEKPSLSAQPGPTVLAGESVTLSCSSWSSYDM YHLSTEGEAHERRFSAGPKVNGTFQADFPLGPATQGGTY RCFGSFHDSPYEWSKSSDPLLVSVTGNPSNSWPSPTEPS SKTGNPRHLHVLIGTSVVKLPFTILLFFLLHRWCSDKKN ASVMDQGPAGNRTVNREDSDEQDHQEVSYA

Database cross reference

RefSeq Protein accession:NP_036445
RefSeq Protein gi:6912474

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005887;C:integral to plasma membrane;TAS:ProtInc.

GO-F

GO:0004872;F:receptor activity;IEA:UniProtKB-KW.

GO-P

GO:0006968;P:cellular defense response;TAS:ProtInc.