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Protein basic information

LiverAtlas Protein ID

HuLPr25900

Uniprot ID

KI3L3_HUMAN

Uniprot Acc

Q8N743;A9PL62;A9PL64;A9PL65;A9PL66;A9PL67;A9PL68;A9PZV4;A9PZV7;A9PZV8;A9Q066;A9Q0R5;A9Q242;A9Q250;A9Q251;O95056;Q1X775;Q1X777;Q1X778;Q1X779;Q1X780;Q1X781;Q1X782;Q1X783;Q7Z7N4;Q8NHI2;Q8NHI3;Q9UEI4;

Protein name

Killer cell immunoglobulin-like receptor 3DL3

Comment

FUNCTION:Receptor on natural killer cells. May inhibit the activity of NK cells thus preventing cell lysis.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type I membrane protein.||POLYMORPHISM:Various different KIR3DL3 alleles are known:KIR3DL3*00101, KIR3DL3*00102, KIR3DL3*00103, KIR3DL3*00201, KIR3DL3*00202, KIR3DL3*00203, KIR3DL3*00204, KIR3DL3*00205, KIR3DL3*00206, KIR3DL3*00207, KIR3DL3*0030101 KIR3DL3*0030102, KIR3DL3*00401, KIR3DL3*00402, KIR3DL3*005, KIR3DL3*00601, KIR3DL3*00602, KIR3DL3*007, KIR3DL3*00801, KIR3DL3*00802, KIR3DL3*00901, KIR3DL3*00902, KIR3DL3*010, KIR3DL3*01101, KIR3DL3*01102, KIR3DL3*012, KIR3DL3*01301, KIR3DL3*01302, KIR3DL3*01303, KIR3DL3*01304, KIR3DL3*01305, KIR3DL3*01306, KIR3DL3*01307, KIR3DL3*01401, KIR3DL3*01402, KIR3DL3*01403, KIR3DL3*01404, KIR3DL3*01405, KIR3DL3*015 KIR3DL3*016, KIR3DL3*017, KIR3DL3*018, KIR3DL3*019, KIR3DL3*020, KIR3DL3*021, KIR3DL3*022, KIR3DL3*023, KIR3DL3*024, KIR3DL3*025, KIR3DL3*026, KIR3DL3*027, KIR3DL3*028, KIR3DL3*029, K

Subcellular localization

Cell membrane;Single-pass type I membrane protein.

Gene name

killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 3

Protein sequence

MSLMVVSMACVGFFLLEGPWPHVGGQDKPFLSAWPGTVVS EGQHVTLQCRSRLGFNEFSLSKEDGMPVPELYNRIFRNS FLMGPVTPAHAGTYRCCSSHPHSPTGWSAPSNPVVIMVT GVHRKPSLLAHPGPLVKSGETVILQCWSDVRFERFLLHR EGITEDPLRLVGQLHDAGSQVNYSMGPMTPALAGTYRCF GSVTHLPYELSAPSDPLDIVVVGLYGKPSLSAQPGPTVQ AGENVTLSCSSRSLFDIYHLSREAEAGELRLTAVLRVNG TFQANFPLGPVTHGGNYRCFGSFRALPHAWSDPSDPLPV SVTGNSRHLHVLIGTSVVIIPFAILLFFLLHRWCANKKN AVVMDQEPAGNRTVNREDSDEQDPQEVTYAQLNHCVFTQ RKITRPSQRPKTPPTDTSV

Database cross reference

RefSeq Protein accession:NP_703144
RefSeq Protein gi:46488946

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0004872;F:receptor activity;IEA:UniProtKB-KW.