Protein basic information
| LiverAtlas Protein ID |
HuLPr25947 |
|
Uniprot ID |
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Uniprot Acc |
Q2M2Z5;B4DDE9;B4DK54;Q4G0M8;Q4G0S5;Q5BKY3;Q6P0M6;Q71ME0;Q9NZ35; |
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Protein name |
Centrosomal protein kizuna |
|
Comment |
FUNCTION:Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.||SUBUNIT:Interacts with AKAP9, CEP72, ODF2, PCNT and TUBGCP2.||INTERACTION:Q3UXL4:Plk1s1 (xeno); NbExp=1; IntAct=EBI-2554344, EBI-2554338;||SUBCELLULAR LOCATION:Cytoplasm, cytoskeleton, centrosome. Note=Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome-surrounding area in a microtubule- independent and dependent manner, respectively.||ALTERNATIVE PRODUCTS:Event=Alternative spl |
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Subcellular localization |
Cytoplasm, cytoskeleton, centrosome. |
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Gene name |
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Protein sequence
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MSRTLASAVPLSSPDYYERLGQLQHGLRDSEKKRLDLEKK LYEYNQSDTCRVKLKYVKLKNYLKEICESEKKAHTRNQE YLKRFERVQAHVVHFTTNTEKLQKLKLEYETQIKKMLCS KDSLGLKEELTDEDREKVAVHEGINSGTAMSRGLYQPAT IFMGRQMSAILSMRDFSTEHKSPQPTKNFSIPDPHSHRQ TAQSSNVTDSCVVQTSNDTQCLNKSDNIDGKASLQIGEK MPVTASVLSEEEQTHCLEIGSNTRHGKSNLSEGKKSAEL NSPLRERLSPENRTTDLKCDSSSGSEGEILTREHIEVEE KRASPPVSPIPVSEYCESENKWSQEKHSPWEGVSDHLAH REPKSQKPFRKMQEEEEESWSTSSDLTISISEDDLILES PEPQPNPGGKMEGEDGIEALKLIHAEQERVALSTEKNCI LQTLSSPDSEKESSTNAPTREPGQTPDSDVPRAQVGQHV ATLKEHDNSVKEEATALLRKALTEECGRRSAIHSSESSC SLPSILNDNSGIKEAKPAVWLNSVPTREQEVSSGCGDKS KKENVAADIPITETEAYQLLKKATLQDNTNQTENRFQKT DASVSHLSGLNIGSGAFETKTANKIASEASFSSSEGSPL SRHENKKKPVINLKSNALWDESDDSNSEIEAALRPRNHNTDDSDDFYD |
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Database cross reference |
RefSeq Protein accession:NP_001156494
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005813;C:centrosome;IDA:UniProtKB. |
|
GO-F |
GO:0019901;F:protein kinase binding;IPI:UniProtKB. |
|
GO-P |
GO:0007051;P:spindle organization;IMP:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr25947 |
PHOSPHORYLATION |
317 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
321 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
647 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
650 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
652 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
56 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
62 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
616 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
618 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
619 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
620 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
379 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
317 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
321 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
647 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
650 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr25947 |
PHOSPHORYLATION |
652 |
S |
PhosphoSitePlus |
LTP |
N |
|
Pathway
| Pathway name |
