HuLPr26028

Uniprot ID

KLOTB_HUMAN

Uniprot Acc

Q86Z14;Q2M3K8;

Protein name

Beta-klotho

Comment

FUNCTION:Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).||SUBUNIT:Interacts with FGFR1 and FGFR4 (By similarity). Interacts with FGF19; this interaction is direct. Interacts (via C-terminus) with FGF21; this interaction is direct.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type III membrane protein (Potential).||DOMAIN:Contains 2 glycosyl hydrolase 1 regions. However, the first region lacks the essential Glu active site residue at position 241, and the second one lacks the essential Glu active site residue at position 889. These domains are therefore predicted to be inactive.||SIMILARITY:Belongs to the glycosyl hydrolase 1 family. Klotho subfamily.

Subcellular localization

Cell membrane;Single-pass type III membrane protein(Potential).

Gene name

klotho beta

Protein sequence

MKPGCAAGSPGNEWIFFSTDEITTRYRNTMSNGGLQRSVI LSALILLRAVTGFSGDGRAIWSKNPNFTPVNESQLFLYD TFPKNFFWGIGTGALQVEGSWKKDGKGPSIWDHFIHTHL KNVSSTNGSSDSYIFLEKDLSALDFIGVSFYQFSISWPR LFPDGIVTVANAKGLQYYSTLLDALVLRNIEPIVTLYHW DLPLALQEKYGGWKNDTIIDIFNDYATYCFQMFGDRVKY WITIHNPYLVAWHGYGTGMHAPGEKGNLAAVYTVGHNLI KAHSKVWHNYNTHFRPHQKGWLSITLGSHWIEPNRSENT MDIFKCQQSMVSVLGWFANPIHGDGDYPEGMRKKLFSVL PIFSEAEKHEMRGTADFFAFSFGPNNFKPLNTMAKMGQN VSLNLREALNWIKLEYNNPRILIAENGWFTDSRVKTEDT TAIYMMKNFLSQVLQAIRLDEIRVFGYTAWSLLDGFEWQ DAYTIRRGLFYVDFNSKQKERKPKSSAHYYKQIIRENGF SLKESTPDVQGQFPCDFSWGVTESVLKPESVASSPQFSD PHLYVWNATGNRLLHRVEGVRLKTRPAQCTDFVNIKKQL EMLARMKVTHYRFALDWASVLPTGNLSAVNRQALRYYRC VVSEGLKLGISAMVTLYYPTHAHLGLPEPLLHADGWLNP STAEAFQAYAGLCFQELGDLVKLWITINEPNRLSDIYNR SGNDTYGAAHNLLVAHALAWRLYDRQFRPSQRGAVSLSL HADWAEPANPYADSHWRAAERFLQFEIAWFAEPLFKTGD YPAAMREYIASKHRRGLSSSALPRLTEAERRLLKGTVDF CALNHFTTRFVMHEQLAGSRYDSDRDIQFLQDITRLSSP TRLAVIPWGVRKLLRWVRRNYGDMDIYITASGIDDQALE DDRLRKYYLGKYLQEVLKAYLIDKVRIKGYYAFKLAEEK SKPRFGFFTSDFKAKSSIQFYNKVISSRGFPFENSSSRC SQTQENTECTVCLFLVQKKPLIFL

Database cross reference

RefSeq Protein accession:NP_783864
RefSeq Protein gi:28376633

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0043169;F:cation binding;IEA:InterPro. GO:0017134;F:fibroblast growth factor binding;IPI:UniProtKB. GO:0004553;F:hydrolase activity, hydrolyzing O-glycosyl compounds;IEA:InterPro.

GO-P

GO:0005975;P:carbohydrate metabolic process;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr26028

PHOSPHORYLATION

880

Y

PhosphoSitePlus

989691

LTP

N

HuLPr26028

PHOSPHORYLATION

886

Y

PhosphoSitePlus

989695

LTP

HTP

N

FGF_signaling_pathway