HuLPr26036

Uniprot ID

KNG1_HUMAN

Uniprot Acc

P01042;A8K474;B2RCR2;P01043;Q53EQ0;Q6PAU9;Q7M4P1;

Protein name

Kininogen-1

Comment

FUNCTION:(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects:(4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved

Subcellular localization

Secreted, extracellular space.

Gene name

kininogen 1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MKLITILFLCSRLLLSLTQESQSEEIDCNDKDLFKAVDAA LKKYNSQNQSNNQFVLYRITEATKTVGSDTFYSFKYEIK EGDCPVQSGKTWQDCEYKDAAKAATGECTATVGKRSSTK FSVATQTCQITPAEGPVVTAQYDCLGCVHPISTQSPDLE PILRHGIQYFNNNTQHSSLFMLNEVKRAQRQVVAGLNFR ITYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYI DIQLRIASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTN SPELEETLTHTITKLNAENNATFYFKIDNVKKARVQVVA GKKYFIDFVARETTCSKESNEELTESCETKKLGQSLDCN AEVYVVPWEKKIYPTVNCQPLGMISLMKRPPGFSPFRSS RIGEIKEETTVSPPHTSMAPAQDEERDSGKEQGHTRRHD WGHEKQRKHNLGHGHKHERDQGHGHQRGHGLGHGHEQQH GLGHGHKFKLDDDLEHQGGHVLDHGHKHKHGHGHGKHKN KGKKNGKHNGWKTEHLASSSEDSTTPSAQTQEKTEGPTP IPSLAKPGVTVTFSDFQDSDLIATMMPPISPAPIQSDDD WIPDIQIDPNGLSFNPISDFPDTTSPKCPGRPWKSVSEI NPTTQMKESYYFDLTDGLS

Database cross reference

RefSeq Protein accession:NP_000884
RefSeq Protein gi:4504893

Yes/No

Yes

Evidence

BodyMap

Quality score

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005615;C:extracellular space;IEA:UniProtKB-SubCell. GO:0005886;C:plasma membrane;TAS:Reactome. GO:0031093;C:platelet alpha granule lumen;TAS:Reactome.

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