Protein basic information
| LiverAtlas Protein ID |
HuLPr26177 |
|
Uniprot ID |
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Uniprot Acc |
Q6P1M3;Q14521;Q9BR62; |
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Protein name |
Lethal(2) giant larvae protein homolog 2 |
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Comment |
FUNCTION:Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity.||SUBUNIT:Interacts with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6. The complex is enhanced during mitosis.||SUBCELLULAR LOCATION:Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=C; IsoId=Q6P1M3-1; Sequence=Displayed; Name=A; IsoId=Q6P1M3-2; Sequence=VSP 017946; Note=No experimental confirmation available; Name=B; IsoId=Q6P1M3-3; Sequence=VSP 017944, VSP 017945; Note=No experimental confirmation available;||PTM:Phosphorylated a |
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Subcellular localization |
Cytoplasm. |
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Gene name |
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Protein sequence
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MRRFLRPGHDPVRERLKRDLFQFNKTVEHGFPHQPSALGY SPSLRILAIGTRSGAIKLYGAPGVEFMGLHQENNAVTQI HLLPGQCQLVTLLDDNSLHLWSLKVKGGASELQEDESFT LRGPPGAAPSATQITVVLPHSSCELLYLGTESGNVFVVQ LPAFRALEDRTISSDAVLQRLPEEARHRRVFEMVEALQE HPRDPNQILIGYSRGLVVIWDLQGSRVLYHFLSSQQLEN IWWQRDGRLLVSCHSDGSYCQWPVSSEAQQPEPLRSLVP YGPFPCKAITRILWLTTRQGLPFTIFQGGMPRASYGDRH CISVIHDGQQTAFDFTSRVIGFTVLTEADPAATFDDPYA LVVLAEEELVVIDLQTAGWPPVQLPYLASLHCSAITCSH HVSNIPLKLWERIIAAGSRQNAHFSTMEWPIDGGTSLTP APPQRDLLLTGHEDGTVRFWDASGVCLRLLYKLSTVRVF LTDTDPNENFSAQGEDEWPPLRKVGSFDPYSDDPRLGIQ KIFLCKYSGYLAVAGTAGQVLVLELNDEAAEQAVEQVEA DLLQDQEGYRWKGHERLAARSGPVRFEPGFQPFVLVQCQ PPAVVTSLALHSEWRLVAFGTSHGFGLFDHQQRRQVFVK CTLHPSDQLALEGPLSRVKSLKKSLRQSFRRMRRSRVSS RKRHPAGPPGEAQEGSAKAERPGLQNMELAPVQRKIEAR SAEDSFTGFVRTLYFADTYLKDSSRHCPSLWAGTNGGTI YAFSLRVPPAERRMDEPVRAEQAKEIQLMHRAPVVGILV LDGHSVPLPEPLEVAHDLSKSPDMQGSHQLLVVSEEQFK VFTLPKVSAKLKLKLTALEGSRVRRVSVAHFGSRRAEDY GEHHLAVLTNLGDIQVVSLPLLKPQVRYSCIRREDVSGI ASCVFTKYGQGFYLISPSEFERFSLSTKWLVEPRCLVDS AETKNHRPGNGAGPKKAPSRARNSGTQSDGEEKQPGLVM ERALLSDERVLKEIQSTLEGDRGS |
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Database cross reference |
RefSeq Protein accession:NP_001015002
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IDA:UniProtKB. GO:0043231;C:intracellular membrane-bounded organelle;IDA:HPA. |
|
GO-F |
GO:0030165;F:PDZ domain binding;IPI:UniProtKB. |
|
GO-P |
GO:0007049;P:cell cycle;IEA:UniProtKB-KW. GO:0051301;P:cell division;IEA:UniProtKB-KW. GO:0006887;P:exocytosis;IEA:UniProtKB-KW. GO:0032878;P:regulation of establishment or maintenance of cell polarity;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr26177 |
PHOSPHORYLATION |
1015 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr26177 |
PHOSPHORYLATION |
965 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr26177 |
PHOSPHORYLATION |
965 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr26177 |
PHOSPHORYLATION |
1015 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr26177 |
PHOSPHORYLATION |
499 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr26177 |
PHOSPHORYLATION |
653 |
S |
PhosphoSitePlus |
LTP |
N |
|
