HuLPr26198

Uniprot ID

LAMA4_HUMAN

Uniprot Acc

Q16363;Q14731;Q14735;Q15335;Q4LE44;Q5SZG8;Q9BTB8;Q9UE18;Q9UJN9;

Protein name

Laminin subunit alpha-4

Comment

FUNCTION:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.||SUBUNIT:Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-4 is a subunit of laminin-8 (laminin-411), laminin-9 (laminin-421) and laminin-14 (laminin-423).||SUBCELLULAR LOCATION:Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q16363-1; Sequence=Displayed; Name=2; IsoId=Q16363-2; Sequence=VSP 017542; Name=3; IsoId=Q16363-3; Sequence=VSP 038853, VSP 038854;||TISSUE SPECIFICITY:In adult, strong expression in heart, lun

Subcellular localization

Secreted, extracellular space, extracellular matrix, basement membrane.

Gene name

laminin, alpha 4

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MALSSAWRSVLPLWLLWSAACSRAASGDDNAFPFDIEGSS AVGRQDPPETSEPRVALGRLPPAAEKCNAGFFHTLSGEC VPCDCNGNSNECLDGSGYCVHCQRNTTGEHCEKCLDGYI GDSIRGAPQFCQPCPCPLPHLANFAESCYRKNGAVRCIC NENYAGPNCERCAPGYYGNPLLIGSTCKKCDCSGNSDPN LIFEDCDEVTGQCRNCLRNTTGFKCERCAPGYYGDARIA KNCAVCNCGGGPCDSVTGECLEEGFEPPTGMDCPTISCD KCVWDLTDALRLAALSIEEGKSGVLSVSSGAAAHRHVNE INATIYLLKTKLSERENQYALRKIQINNAENTMKSLLSD VEELVEKENQASRKGQLVQKESMDTINHASQLVEQAHDM RDKIQEINNKMLYYGEEHELSPKEISEKLVLAQKMLEEI RSRQPFFTQRELVDEEADEAYELLSQAESWQRLHNETRT LFPVVLEQLDDYNAKLSDLQEALDQALNYVRDAEDMNRA TAARQRDHEKQQERVREQMEVVNMSLSTSADSLTTPRLT LSELDDIIKNASGIYAEIDGAKSELQVKLSNLSNLSHDL VQEAIDHAQDLQQEANELSRKLHSSDMNGLVQKALDASN VYENIVNYVSEANETAEFALNTTDRIYDAVSGIDTQIIY HKDESENLLNQARELQAKAESSSDEAVADTSRRVGGALA RKSALKTRLSDAVKQLQAAERGDAQQRLGQSRLITEEAN RTTMEVQQATAPMANNLTNWSQNLQHFDSSAYNTAVNSA RDAVRNLTEVVPQLLDQLRTVEQKRPASNVSASIQRIRE LIAQTRSVASKIQVSMMFDGQSAVEVHSRTSMDDLKAFT SLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLA IKNDNLVYVYNLGTKDVEIPLDSKPVSSWPAYFSIVKIE RVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLLDLD PEDTVFYVGGVPSNFKLPTSLNLP

Database cross reference

RefSeq Protein accession:NP_001098676
RefSeq Protein gi:157419124

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005606;C:laminin-1 complex;IEA:InterPro.

GO-F

GO:0005201;F:extracellular matrix structural constituent;TAS:ProtInc. GO:0005102;F:receptor binding;IEA:InterPro.

GO-P

GO:0007155;P:cell adhesion;IEA:UniProtKB-KW. GO:0030155;P:regulation of cell adhesion;IEA:InterPro. GO:0030334;P:regulation of cell migration;IEA:InterPro. GO:0045995;P:regulation of embryonic development;IEA:InterPro.