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Protein basic information

LiverAtlas Protein ID

HuLPr26204

Uniprot ID

LAMC1_HUMAN

Uniprot Acc

P11047;Q5VYE7;

Protein name

Laminin subunit gamma-1

Comment

FUNCTION:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.||SUBUNIT:Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Gamma-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2 (laminin-211 or merosin), laminin-3 (laminin- 121 or S-laminin), laminin-4 (laminin-221 or S-merosin), laminin-6 (laminin-311 or K-laminin), laminin-7 (laminin-321 or KS-laminin), laminin-8 (laminin-411), laminin-9 (laminin-421), laminin-10 (laminin-511) and laminin-11 (laminin-521).||SUBCELLULAR LOCATION:Secreted, extracellular space, extracellular matrix, basement membrane.||TISSUE SPECIFICITY:Found in the basement membr

Subcellular localization

Secreted, extracellular space, extracellular matrix, basement membrane.

Gene name

laminin, gamma 1 (formerly LAMB2)

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MRGSHRAAPALRPRGRLWPVLAVLAAAAAAGCAQAAMDEC TDEGGRPQRCMPEFVNAAFNVTVVATNTCGTPPEEYCVQ TGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWW QSQTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRP ESFAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRT GGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFD NSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYY YAISDFAVGGRCKCNGHASECMKNEFDKLVCNCKHNTYG VDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECY FDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGN NEACSSCHCSPVGSLSTQCDSYGRCSCKPGVMGDKCDRC QPGFHSLTEAGCRPCSCDPSGSIDECNIETGRCVCKDNV EGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAV GYSVYSISSTFQIDEDGWRAEQRDGSEASLEWSSERQDI AVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVDRR DTRLSAEDLVLEGAGLRVSVPLIAQGNSYPSETTVKYVF RLHEATDYPWRPALTPFEFQKLLNNLTSIKIRGTYSERS AGYLDDVTLASARPGPGVPATWVESCTCPVGYGGQFCEM CLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVCNC RDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSC AVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNG PVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGF YCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSC NPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDC HALGSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFG PEGCKPCDCHPEGSLSLQCKDDGR

Database cross reference

RefSeq Protein accession:NP_002284
RefSeq Protein gi:145309326

Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005615;C:extracellular space;NAS:UniProtKB. GO:0005606;C:laminin-1 complex;NAS:UniProtKB. GO:0043259;C:laminin-10 complex;TAS:BHF-UCL. GO:0043260;C:laminin-11 complex;TAS:BHF-UCL.

GO-F

GO:0005201;F:extracellular matrix structural constituent;IMP:HGNC.

GO-P

GO:0007411;P:axon guidance;TAS:Reactome. GO:0016477;P:cell migration;IMP:HGNC. GO:0007492;P:endoderm development;TAS:ProtInc. GO:0022617;P:extracellular matrix disassembly;IMP:HGNC. GO:0 Error!!! Error!!!Go back to the login page