HuLPr26238

Uniprot ID

LAT3_HUMAN

Uniprot Acc

O75387;

Protein name

Large neutral amino acids transporter small subunit 3

Comment

FUNCTION:Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer.||SUBCELLULAR LOCATION:Membrane; Multi-pass membrane protein (Probable).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=2.3kb; IsoId=O75387-1; Sequence=Displayed; Name=2; Synonyms=5kb; IsoId=O75387-2; Sequence=VSP 051620;||TISSUE SPECIFICITY:In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells.||MISCELLANEOUS:Up-regulated in early prostate cancer development with highest expression level in seminomas of testicular germ cell tumors.||SIMILARITY:Belongs to the SLC43A t

Subcellular localization

Membrane;Multi-pass membrane protein(Probable).

Gene name

solute carrier family 43, member 1

Protein sequence

MAPTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIIL KNEGFYSSTCPAESSTNTTQDEQRRWPGCDQQDEMLNLG FTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASC TLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLP NMFGNLRSTLMALMIGSYASSAITFPGIKLIYDAGVAFV VIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYTKKIK LSGLALDHKVTGDLFYTHVTTMGQRLSQKAPSLEDGSDA FMSPQDVRGTSENLPERSVPLRKSLCSPTFLWSLLTMGM TQLRIIFYMAAVNKMLEYLVTGGQEHETNEQQQKVAETV GFYSSVFGAMQLLCLLTCPLIGYIMDWRIKDCVDAPTQG TVLGDARDGVATKSIRPRYCKIQKLTNAISAFTLTNLLL VGFGITCLINNLHLQFVTFVLHTIVRGFFHSACGSLYAA VFPSNHFGTLTGLQSLISAVFALLQQPLFMAMVGPLKGE PFWVNLGLLLFSLLGFLLPSYLFYYRARLQQEYAANGMGPLKVLSGSEVTA

Database cross reference

RefSeq Protein accession:NP_001185739
RefSeq Protein gi:311771737

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005887;C:integral to plasma membrane;TAS:UniProtKB.

GO-F

GO:0015175;F:neutral amino acid transmembrane transporter activity;IDA:UniProtKB.

GO-P

GO:0034641;P:cellular nitrogen compound metabolic process;TAS:Reactome. GO:0006811;P:ion transport;TAS:Reactome.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr26238

PHOSPHORYLATION

267

S

PhosphoSitePlus

4753283

HTP

yes