Protein basic information
| LiverAtlas Protein ID |
HuLPr26284 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q96JN0;D3DR47;Q5VW16;Q7Z723;Q86T32;Q86T33;Q8N3L6; |
|
Protein name |
Ligand-dependent corepressor |
|
Comment |
FUNCTION:May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand- dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.||SUBUNIT:Interacts with ESR1 and ESR2 in the presence of estradiol. Interacts with CTBP1, HDAC3 and HDAC6. Component of a large corepressor complex that contains about 20 proteins, including CTBP1, CTBP2, HDAC1 and HDAC2.||SUBCELLULAR LOCATION:Nucleus.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96JN0-1; Sequence=Displayed; Name=2; IsoId=Q96JN0-2; Sequence=VSP 018585, VSP 018586;||TISSUE SPECIFICITY:Ubiquitous.||SIMILARITY:Contains 1 HTH psq-type DNA-binding domain.||SEQUENCE CAUTION:Sequence=BAB47424.1; Type=Erroneous initiation; |
|
Subcellular localization |
Nucleus. |
|
Gene name |
|
|
Protein sequence
|
MQRMIQQFAAEYTSKNSSTQDPSQPNSTKNQSLPKASPVT TSPTAATTQNPVLSKLLMADQDSPLDLTVRKSQSEPSEQ DGVLDLSTKKSPCAGSTSLSHSPGCSSTQGNGRPGRPSQ YRPDGLRSGDGVPPRSLQDGTREGFGHSTSLKVPLARSL QISEELLSRNQLSTAASLGPSGLQNHGQHLILSREASWA KPHYEFNLSRMKFRGNGALSNISDLPFLAENSAFPKMAL QAKQDGKKDVSHSSPVDLKIPQVRGMDLSWESRTGDQYS YSSLVMGSQTESALSKKLRAILPKQSRKSMLDAGPDSWG SDAEQSTSGQPYPTSDQEGDPGSKQPRKKRGRYRQYNSE ILEEAISVVMSGKMSVSKAQSIYGIPHSTLEYKVKERLG TLKNPPKKKMKLMRSEGPDVSVKIELDPQGEAAQSANESKNE |
|
Database cross reference |
RefSeq Protein accession:NP_001164236
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. |
|
GO-F |
GO:0003677;F:DNA binding;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr26284 |
PHOSPHORYLATION |
351 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr26284 |
PHOSPHORYLATION |
359 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr26284 |
PHOSPHORYLATION |
363 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr26284 |
PHOSPHORYLATION |
367 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr26284 |
PHOSPHORYLATION |
37 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr26284 |
PHOSPHORYLATION |
42 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr26284 |
PHOSPHORYLATION |
249 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr26284 |
PHOSPHORYLATION |
426 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr26284 |
PHOSPHORYLATION |
63 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr26284 |
PHOSPHORYLATION |
359 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr26284 |
PHOSPHORYLATION |
363 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr26284 |
PHOSPHORYLATION |
42 |
S |
PhosphoSitePlus |
LTP |
N |
|
