HuLPr26295

Uniprot ID

LDHD_HUMAN

Uniprot Acc

Q86WU2;Q8IZK5;

Protein name

Probable D-lactate dehydrogenase, mitochondrial

Comment

CATALYTIC ACTIVITY:(R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c.||COFACTOR:FAD (By similarity).||SUBUNIT:Interacts with CSRP3.||SUBCELLULAR LOCATION:Mitochondrion (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q86WU2-1; Sequence=Displayed; Note=No experimental confirmation available; Name=2; IsoId=Q86WU2-2; Sequence=VSP 052253;||TISSUE SPECIFICITY:Expressed moderately in heart and liver and at lower levels in skeletal muscle and kidney.||SIMILARITY:Belongs to the FAD-binding oxidoreductase/transferase type 4 family.||SIMILARITY:Contains 1 FAD-binding PCMH-type domain.||SEQUENCE CAUTION:Sequence=AAM50322.1; Type=Frameshift; Positions=Several;

Subcellular localization

Mitochondrion(By similarity).

Gene name

lactate dehydrogenase D

Protein sequence

MARLLRSATWELFPWRGYCSQKAKGELCRDFVEALKAVVG GSHVSTAAVVREQHGRDESVHRCEPPDAVVWPQNVEQVS RLAALCYRQGVPIIPFGTGTGLEGGVCAVQGGVCVNLTH MDRILELNQEDFSVVVEPGVTRKALNAHLRDSGLWFPVD PGADASLCGMAATGASGTNAVRYGTMRDNVLNLEVVLPD GRLLHTAGRGRHFRFGFWPEIPHHTAWYSPCVSLGRRKS AAGYNLTGLFVGSEGTLGLITATTLRLHPAPEATVAATC AFPSVQAAVDSTVHILQAAVPVARIEFLDEVMMDACNRY SKLNCLVAPTLFLEFHGSQQALEEQLQRTEEIVQQNGAS DFSWAKEAEERSRLWTARHNAWYAALATRPGCKGYSTDV CVPISRLPEIVVQTKEDLNASGLTGSIVGHVGDGNFHCI LLVNPDDAEELGRVKAFAEQLGRRALALHGTCTGEHGIG MGKRQLLQEEVGAVGVETMRQLKAVLDPQGLMNPGKVL

Database cross reference

RefSeq Protein accession:NP_705690
RefSeq Protein gi:37595754

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

GO-F

GO:0004458;F:D-lactate dehydrogenase (cytochrome) activity;IEA:EC. GO:0050660;F:flavin adenine dinucleotide binding;IEA:InterPro. GO:0005515;F:protein binding;IPI:UniProtKB.

GO-P

GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW.

Pyruvate_Metabolism

Leigh_Syndrome