Protein basic information
| LiverAtlas Protein ID |
HuLPr26330 |
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Uniprot ID |
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Uniprot Acc |
O00292;B3KNH4;O75611;Q5TE89;Q8NBQ9; |
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Protein name |
Left-right determination factor 2 |
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Comment |
FUNCTION:Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:Mesenchymal cells of the endometrial stroma.||DEVELOPMENTAL STAGE:Transiently expressed before and during menstrual bleeding.||PTM:The processing of the protein may also occur at the second R- X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.||DISEASE:Defects in LEFTY2 are the cause of left-right axis malformations (L-R axis malformation) [MIM:601877]. The defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.||SIMILARITY:Belongs to the TGF-beta family.||SEQUENCE CAUTION:Sequence=AAB53269.1; Type=Miscellaneous discrepancy; Note=Authors have revised their sequence, but have not submitted the revised DNA sequence;||WEB RESOU |
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Subcellular localization |
Secreted. |
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Gene name |
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Protein sequence
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MWPLWLCWALWVLPLAGPGAALTEEQLLGSLLRQLQLSEV PVLDRADMEKLVIPAHVRAQYVVLLRRSHGDRSRGKRFS QSFREVAGRFLASEASTHLLVFGMEQRLPPNSELVQAVL RLFQEPVPKAALHRHGRLSPRSAQARVTVEWLRVRDDGS NRTSLIDSRLVSVHESGWKAFDVTEAVNFWQQLSRPRQP LLLQVSVQREHLGPLASGAHKLVRFASQGAPAGLGEPQL ELHTLDLRDYGAQGDCDPEAPMTEGTRCCRQEMYIDLQG MKWAKNWVLEPPGFLAYECVGTCQQPPEALAFNWPFLGP RQCIASETASLPMIVSIKEGGRTRPQVVSLPNMRVQKCS CASDGALVPRRLQP |
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Database cross reference |
RefSeq Protein accession:NP_001165896
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005615;C:extracellular space;IEA:UniProtKB-KW. GO:0031093;C:platelet alpha granule lumen;TAS:Reactome. |
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GO-F |
GO:0005125;F:cytokine activity;IEA:UniProtKB-KW. GO:0008083;F:growth factor activity;IEA:UniProtKB-KW. GO:0005160;F:transforming growth factor beta receptor binding;IEA:InterPro. |
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GO-P |
GO:0016049;P:cell growth;IEA:InterPro. GO:0007275;P:multicellular organismal development;TAS:ProtInc. GO:0030168;P:platelet activation;TAS:Reactome. GO:0002576;P:platelet degranulation;TAS:Reactome. GO:0007179;P:transforming growth factor beta receptor |
Pathway
| Pathway name |
