HuLPr26387

Uniprot ID

LIPC_HUMAN

Uniprot Acc

P11150;A2RUB4;A8K9B6;O43571;P78529;Q99465;

Protein name

Hepatic triacylglycerol lipase

Comment

FUNCTION:Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.||CATALYTIC ACTIVITY:Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.||SUBCELLULAR LOCATION:Secreted.||POLYMORPHISM:Genetic variations in LIPC define the high density lipoprotein cholesterol level quantitative trait locus 12 (HDLCQ12) [MIM:612797].||POLYMORPHISM:Genetic variations in LIPC are associated with non- insulin-dependent diabetes mellitus susceptibility (NIDDM susceptibility) [MIM:151670].||DISEASE:Defects in LIPC are the cause of hepatic lipase deficiency (HL deficiency) [MIM:151670].||SIMILARITY:Belongs to the AB hydrolase superfamily. Lipase family.||SIMILARITY:Contains 1 PLAT domain.||WEB RESOURCE:Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=LIPC";

Subcellular localization

Secreted.

Gene name

lipase, hepatic

Protein sequence

MDTSPLCFSILLVLCIFIQSSALGQSLKPEPFGRRAQAVE TNKTLHEMKTRFLLFGETNQGCQIRINHPDTLQECGFNS SLPLVMIIHGWSVDGVLENWIWQMVAALKSQPAQPVNVG LVDWITLAHDHYTIAVRNTRLVGKEVAALLRWLEESVQL SRSHVHLIGYSLGAHVSGFAGSSIGGTHKIGRITGLDAA GPLFEGSAPSNRLSPDDANFVDAIHTFTREHMGLSVGIK QPIGHYDFYPNGGSFQPGCHFLELYRHIAQHGFNAITQT IKCSHERSVHLFIDSLLHAGTQSMAYPCGDMNSFSQGLC LSCKKGRCNTLGYHVRQEPRSKSKRLFLVTRAQSPFKVY HYQFKIQFINQTETPIQTTFTMSLLGTKEKMQKIPITLG KGIASNKTYSFLITLDVDIGELIMIKFKWENSAVWANVW DTVQTIIPWSTGPRHSGLVLKTIRVKAGETQQRMTFCSE NTDDLLLRPTQEKIFVKCEIKSKTSKRKIR

Database cross reference

RefSeq Protein accession:NP_000227
RefSeq Protein gi:194097335

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Fetal Liver;Human Liver Organelles;

GO:0034364;C:high-density lipoprotein particle;IEA:UniProtKB-KW.

GO-F

GO:0034185;F:apolipoprotein binding;ISS:BHF-UCL. GO:0008201;F:heparin binding;IEA:UniProtKB-KW. GO:0030169;F:low-density lipoprotein particle binding;ISS:BHF-UCL. GO:0004620;F:phospholipase activity;TAS:BHF-UCL. GO:0004806;F:triglyceride lipase activit

GO-P

GO:0042632;P:cholesterol homeostasis;IMP:BHF-UCL. GO:0034382;P:chylomicron remnant clearance;TAS:BHF-UCL. GO:0006633;P:fatty acid biosynthetic process;IDA:BHF-UCL. GO:0034375;P:high-density lipoprotein particle remodeling;IMP:BHF-UCL. GO:0034373;P:inte

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr26387

PHOSPHORYLATION

347

S

PhosphoSitePlus

3147570

LTP

N

Glycerolipid_Metabolism