HuLPr26404

Uniprot ID

LIRA5_HUMAN

Uniprot Acc

A6NI73;A6NHI3;

Protein name

Leukocyte immunoglobulin-like receptor subfamily A member 5

Comment

FUNCTION:May plays a role in triggering innate immune responses. Seems not play a role for any class I MHC antigens recognition.||SUBCELLULAR LOCATION:Isoform 1:Membrane; Single-pass type I membrane protein. Secreted.||SUBCELLULAR LOCATION:Isoform 2:Membrane; Single-pass type I membrane protein. Secreted.||SUBCELLULAR LOCATION:Isoform 3:Secreted.||SUBCELLULAR LOCATION:Isoform 4:Secreted.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=LIR9m1; IsoId=A6NI73-1; Sequence=Displayed; Name=2; Synonyms=LIR9m2; IsoId=A6NI73-2; Sequence=VSP 031276; Name=3; Synonyms=LIR9s1; IsoId=A6NI73-3; Sequence=VSP 031277; Name=4; Synonyms=LIR9s2; IsoId=A6NI73-4; Sequence=VSP 031276, VSP 031277;||TISSUE SPECIFICITY:Expressed mostly in tissues of the hematopoitic system, including bone marrow, spleen, lymph node and peripheral leukocytes. Among leukocytes, monocytes and neutrophils express the highest level. Expressed in CD14+ monocytes, but not in T-cells, B-cells

Subcellular localization

Isoform 1:Membrane;Single-pass type I membrane protein.Secreted.

Gene name

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5

Protein sequence

MAPWSHPSAQLQPVGGDAVSPALMVLLCLGLSLGPRTHVQ AGNLSKATLWAEPGSVISRGNSVTIRCQGTLEAQEYRLV KEGSPEPWDTQNPLEPKNKARFSIPSMTEHHAGRYRCYY YSPAGWSEPSDPLELVVTGFYNKPTLSALPSPVVTSGEN VTLQCGSRLRFDRFILTEEGDHKLSWTLDSQLTPSGQFQ ALFPVGPVTPSHRWMLRCYGSRRHILQVWSEPSDLLEIP VSGAADNLSPSQNKSDSGTASHLQDYAVENLIRMGMAGL ILVVLGILIFQDWHSQRSPQAAAGR

Database cross reference

RefSeq Protein accession:NP_067073
RefSeq Protein gi:32490553

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0004872;F:receptor activity;IEA:UniProtKB-KW.

GO-P

GO:0045087;P:innate immune response;IEA:UniProtKB-KW.