Protein basic information
| LiverAtlas Protein ID |
HuLPr26410 |
|
Uniprot ID |
|
|
Uniprot Acc |
O75023;Q8N760; |
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Protein name |
Leukocyte immunoglobulin-like receptor subfamily B member 5 |
|
Comment |
FUNCTION:May act as receptor for class I MHC antigens.||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O75023-1; Sequence=Displayed; Name=2; IsoId=O75023-2; Sequence=VSP 008461, VSP 008462; Note=No experimental confirmation available; Name=3; IsoId=O75023-3; Sequence=VSP 008462; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Detected in a natural killer (NK) cells.||DOMAIN:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.||SIMILARITY:Contains 4 Ig-like C2-type (immunoglobulin-like) domains. |
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Subcellular localization |
Membrane;Single-pass type I membrane protein. |
|
Gene name |
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 |
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Protein sequence
|
MTLTLSVLICLGLSVGPRTCVQAGTLPKPTLWAEPASVIA RGKPVTLWCQGPLETEEYRLDKEGLPWARKRQNPLEPGA KAKFHIPSTVYDSAGRYRCYYETPAGWSEPSDPLELVAT GFYAEPTLLALPSPVVASGGNVTLQCDTLDGLLTFVLVE EEQKLPRTLYSQKLPKGPSQALFPVGPVTPSCRWRFRCY YYYRKNPQVWSNPSDLLEILVPGVSRKPSLLIPQGSVVA RGGSLTLQCRSDVGYDIFVLYKEGEHDLVQGSGQQPQAG LSQANFTLGPVSRSHGGQYRCYGAHNLSPRWSAPSDPLD ILIAGLIPDIPALSVQPGPKVASGENVTLLCQSWHQIDT FFLTKEGAAHPPLCLKSKYQSYRHQAEFSMSPVTSAQGG TYRCYSAIRSYPYLLSSPSYPQELVVSGPSGDPSLSPTG STPTPGPEDQPLTPTGLDPQSGLGRHLGVVTGVSVAFVL LLFLLLFLLLRHRHQSKHRTSAHFYRPAGAAGPEPKDQG LQKRASPVADIQEEILNAAVKDTQPKDGVEMDARAAASE APQDVTYAQLHSLTLRREATEPPPSQEREPPAEPSIYAPLAIH |
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Database cross reference |
RefSeq Protein accession:NP_001074911
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
|
GO-F |
GO:0004888;F:transmembrane receptor activity;TAS:ProtInc. |
|
GO-P |
GO:0007166;P:cell surface receptor linked signaling pathway;TAS:ProtInc. GO:0006952;P:defense response;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr26410 |
PHOSPHORYLATION |
514 |
S |
PhosphoSitePlus |
LTP |
yes |
 
|
