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Protein basic information

LiverAtlas Protein ID

HuLPr26474

Uniprot ID

LPAR3_HUMAN

Uniprot Acc

Q9UBY5;A0AVA3;

Protein name

Lysophosphatidic acid receptor 3

Comment

FUNCTION:Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.||SIMILARITY:Belongs to the G-protein coupled receptor 1 family.

Subcellular localization

Cell membrane;Multi-pass membrane protein.

Gene name

lysophosphatidic acid receptor 3

Protein sequence

MNECHYDKHMDFFYNRSNTDTVDDWTGTKLVIVLCVGTFF CLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFA GIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLT NLLVIAVERHMSIMRMRVHSNLTKKRVTLLILLVWAIAI FMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNL MAFLIMVVVYLRIYVYVKRKTNVLSPHTSGSISRRRTPM KLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCRQCGVQHV KRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCFSQ ENPERRPSRIPSTVLSRSDTGSQYIEDSISQGAVCNKSTS

Database cross reference

RefSeq Protein accession:NP_036284
RefSeq Protein gi:6912348

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005887;C:integral to plasma membrane;TAS:ProtInc. GO:0043231;C:intracellular membrane-bounded organelle;IDA:HPA.

GO-P

GO:0007187;P:G-protein signaling, coupled to cyclic nucleotide second messenger;TAS:ProtInc. GO:0007268;P:synaptic transmission;TAS:ProtInc.

Pathway

Pathway name

LPA_receptor_mediated_events