Protein basic information
| LiverAtlas Protein ID |
HuLPr26485 |
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Uniprot ID |
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Uniprot Acc |
Q9BQK8;B2RTT5;Q5TDB9;Q9NPY8;Q9UJE5; |
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Protein name |
Phosphatidate phosphatase LPIN3 |
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Comment |
FUNCTION:Regulates fatty acid metabolism. Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis (By similarity).||CATALYTIC ACTIVITY:A 1,2-diacylglycerol 3-phosphate + H(2)O = a 1,2-diacyl-sn-glycerol + phosphate.||COFACTOR:Mg(2+) (By similarity).||ENZYME REGULATION:Inhibited by N-ethylmaleimide (By similarity).||SUBCELLULAR LOCATION:Nucleus (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BQK8-1; Sequence=Displayed; Name=2; IsoId=Q9BQK8-2; Sequence=VSP 036885; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Significant expression in intestine and other regions of the gastrointestinal tract.||DOMAIN:Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity (By similarity).||DOMAIN:Contains one Leu-Xaa |
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Subcellular localization |
Nucleus(Potential). |
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Gene name |
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Related liver disease name |
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Protein sequence
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MNYVGQLAETVFGTVKELYRGLNPATLSGGIDVLVVKQVD GSFRCSPFHVRFGKLGVLRSREKVVDIELNGEPVDLHMK LGDSGEAFFVQELESDDEHVPPGLCTSPIPWGGLSGFPS DSQLGTASEPEGLVMAGTASTGRRKRRRRRKPKQKEDAV ATDSSPEELEAGAESELSLPEKLRPEPPGVQLEEKSSLQ PKDIYPYSDGEWPPQASLSAGELTSPKSDSELEVRTPEP SPLRAESHMQWAWGRLPKVARAERPESSVVLEGRAGATS PPRGGPSTPSTSVAGGVDPLGLPIQQTEAGADLQPDTED PTLVGPPLHTPETEESKTQSSGDMGLPPASKSWSWATLE VPVPTGQPERVSRGKGSPKRSQHLGPSDIYLDDLPSLDS ENAALYFPQSDSGLGARRWSEPSSQKSLRDPNPEHEPEP TLDTVDTIALSLCGGLADSRDISLEKFNQHSVSYQDLTK NPGLLDDPNLVVKINGKHYNWAVAAPMILSLQAFQKNLP KSTMDKLEREKMPRKGGRWWFSWRRRDFLAEERSAQKEK TAAKEQQGEKTEVLSSDDDAPDSPVILEIPSLPPSTPPS TPTYKKSLRLSSDQIRRLNLQEGANDVVFSVTTQYQGTC RCKATIYLWKWDDKVVISDIDGTITKSDALGHILPQLGK DWTHQGITSLYHKIQLNGYKFLYCSARAIGMADLTKGYL QWVSEGGCSLPKGPILLSPSSLFSALHREVIEKKPEVFK VACLSDIQQLFLPHGQPFYAAFGNRPNDVFAYRQVGLPE SRIFTVNPRGELIQELIKNHKSTYERLGEVVELLFPPVA RGPSTDLANPEYSNFCYWREPLPAVDLDTLD |
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Database cross reference |
RefSeq Protein accession:NP_075047
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005634;C:nucleus;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0008195;F:phosphatidate phosphatase activity;IEA:EC. |
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GO-P |
GO:0006631;P:fatty acid metabolic process;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr26485 |
PHOSPHORYLATION |
159 |
T |
Phospho-ELM |
HTP |
N |
 
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HuLPr26485 |
PHOSPHORYLATION |
161 |
S |
Phospho-ELM |
HTP |
N |
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HuLPr26485 |
PHOSPHORYLATION |
162 |
S |
Phospho-ELM |
HTP |
N |
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HuLPr26485 |
PHOSPHORYLATION |
161 |
S |
PhosphoSitePlus |
HTP |
N |
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HuLPr26485 |
PHOSPHORYLATION |
162 |
S |
PhosphoSitePlus |
LTP |
N |
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HuLPr26485 |
PHOSPHORYLATION |
159 |
T |
PhosphoSitePlus |
LTP |
N |
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