HuLPr26514

Uniprot ID

LRC17_HUMAN

Uniprot Acc

Q8N6Y2;Q13288;Q6UWA7;Q75MG5;

Protein name

Leucine-rich repeat-containing protein 17

Comment

FUNCTION:Involved in bone homeostasis. Acts as a negative regulator of RANKL-induced osteoclast precursor differentiation from bone marrow precursors (By similarity).||SUBCELLULAR LOCATION:Secreted, extracellular space (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8N6Y2-1; Sequence=Displayed; Name=2; IsoId=Q8N6Y2-2; Sequence=VSP 011424, VSP 011425;||TISSUE SPECIFICITY:Expressed in osteoblast cell lines. Well expressed in ovary, heart, pancreas, skeletal muscle, lung, and fetal kidney and lung and only at the basal levels in the other tissues examined including adult kidney. More expressed in S-type neuroblastoma cells than in N-type neuroblastoma cells.||SIMILARITY:Contains 6 LRR (leucine-rich) repeats.||SIMILARITY:Contains 2 LRRCT domains.||SIMILARITY:Contains 1 LRRNT domain.

Subcellular localization

Secreted, extracellular space(By similarity).

Gene name

leucine rich repeat containing 17

Protein sequence

MRVVTIVILLCFCKAAELRKASPGSVRSRVNHGRAGGGRR GSNPVKRYAPGLPCDVYTYLHEKYLDCQERKLVYVLPGW PQDLLHMLLARNKIRTLKNNMFSKFKKLKSLDLQQNEIS KIESEAFFGLNKLTTLLLQHNQIKVLTEEVFIYTPLLSY LRLYDNPWHCTCEIETLISMLQIPRNRNLGNYAKCESPQ EQKNKKLRQIKSEQLCNEEEKEQLDPKPQVSGRPPVIKP EVDSTFCHNYVFPIQTLDCKRKELKKVPNNIPPDIVKLD LSYNKINQLRPKEFEDVHELKKLNLSSNGIEFIDPAAFL GLTHLEELDLSNNSLQNFDYGVLEDLYFLKLLWLRDNPW RCDYNIHYLYYWLKHHYNVHFNGLECKTPEEYKGWSVGK YIRSYYEECPKDKLPAYPESFDQDTEDDEWEKKHRDHTA KKQSVIITIVG

Database cross reference

RefSeq Protein accession:NP_001026862
RefSeq Protein gi:72534676

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005615;C:extracellular space;ISS:UniProtKB.

GO-P

GO:0048539;P:bone marrow development;ISS:UniProtKB. GO:0045671;P:negative regulation of osteoclast differentiation;ISS:UniProtKB. GO:0001503;P:ossification;IEA:UniProtKB-KW.