Protein basic information
LiverAtlas Protein ID |
HuLPr26538 |
Uniprot ID |
|
Uniprot Acc |
Q9NT99;Q3ZCQ4;Q58F20; |
Protein name |
Leucine-rich repeat-containing protein 4B |
Comment |
FUNCTION:Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).||SUBUNIT:Interacts with PTPRF (By similarity). Interacts with DLG4 (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass membrane protein. Cell junction, synapse, presynaptic cell membrane (By similarity).||DOMAIN:The last 4 C-terminal residues bind to the first 2 PDZ domains of DLG4 (By similarity).||PTM:N-glycosylated (By similarity). O-glycosylated; contains sialic acid (By similarity).||SIMILARITY:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.||SIMILARITY:Contains 9 LRR (leucine-rich) repeats.||SIMILARITY:Contains 1 LRRCT domain.||SIMILARITY:Contains 1 LRRNT domain.||SEQUENCE CAUTION:Sequence=AAH19687.1; Type=Erroneous initiation; |
Subcellular localization |
Membrane;Single-pass membrane protein.Cell junction, synapse, presynaptic cell membrane(By similarity). |
Gene name |
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Protein sequence
|
MARARGSPCPPLPPGRMSWPHGALLFLWLFSPPLGAGGGG VAVTSAAGGGSPPATSCPVACSCSNQASRVICTRRDLAE VPASIPVNTRYLNLQENGIQVIRTDTFKHLRHLEILQLS KNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYL SKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLE YISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEELE LSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFD DLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPW HCNCDVLWLSWWLKETVPSNTTCCARCHAPAGLKGRYIG ELDQSHFTCYAPVIVEPPTDLNVTEGMAAELKCRTGTSM TSVNWLTPNGTLMTHGSYRVRISVLHDGTLNFTNVTVQD TGQYTCMVTNSAGNTTASATLNVSAVDPVAAGGTGSGGG GPGGSGGVGGGSGGYTYFTTVTVETLETQPGEEALQPRG TEKEPPGPTTDGVWGGGRPGDAAGPASSSTTAPAPRSSR PTEKAFTVPITDVTENALKDLDDVMKTTKIIIGCFVAIT FMAAVMLVAFYKLRKQHQLHKHHGPTRTVEIINVEDELP AASAVSVAAAAAVASGGGVGGDSHLALPALERDHLNHHH YVAAAFKAHYSSNPSGGGCGGKGPPGLNSIHEPLLFKSGSKENVQETQI |
Database cross reference |
RefSeq Protein accession:NP_001073926
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Liver relevance
HLPP validation |
Yes/No |
Yes |
Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
GO-C |
GO:0030054;C:cell junction;IEA:UniProtKB-KW. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0042734;C:presynaptic membrane;IEA:UniProtKB-SubCell. |