Protein basic information
| LiverAtlas Protein ID |
HuLPr26591 |
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Uniprot ID |
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Uniprot Acc |
O75197;Q96TD6;Q9UP66; |
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Protein name |
Low-density lipoprotein receptor-related protein 5 |
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Comment |
FUNCTION:Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor- ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3- mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.||SUBUNIT:Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling (By similarity). Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts with FZD8; the interaction is formed on WNT-binding and signaling. |
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Subcellular localization |
Membrane;Single-pass type I membrane protein.Endoplasmic reticulum(By similarity). |
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Gene name |
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Protein sequence
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MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANR RDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYW TDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWV GKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIA LDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYW PNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEG SLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEI LSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLS PSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDL RRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTD DEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNL YWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPV MGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGL ALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPH IFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLP DLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRC GCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNN NDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAF MNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRI EVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWG GKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYW TDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIY WTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSS RQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPS SRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGL RNVKAIDYDPLDKFIYWVDGRQNI |
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Database cross reference |
RefSeq Protein accession:NP_002326
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005783;C:endoplasmic reticulum;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IDA:BHF-UCL. GO:0043235;C:receptor complex;IDA:BHF-UCL. |
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GO-F |
GO:0005515;F:protein binding;IPI:BHF-UCL. GO:0004872;F:receptor activity;IEA:UniProtKB-KW. |
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GO-P |
GO:0060612;P:adipose tissue development;IMP:BHF-UCL. GO:0048539;P:bone marrow development;IMP:BHF-UCL. GO:0060349;P:bone morphogenesis;IMP:BHF-UCL. GO:0060070;P:canonical Wnt receptor signaling pathway;IDA:BHF-UCL. GO:0042632;P:cholesterol homeostasis; |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr26591 |
PHOSPHORYLATION |
1552 |
Y |
PhosphoSitePlus |
LTP |
N |
 
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Pathway
| Pathway name | |
| Pathway name | |
| Pathway name |
