HuLPr26637

Uniprot ID

LST2_HUMAN

Uniprot Acc

Q9HCC9;B2RP83;B3KX50;B7Z1Q7;B7Z2G9;B7Z2M2;B7ZB19;

Protein name

Lateral signaling target protein 2 homolog

Comment

FUNCTION:Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when not monoubiquitinated.||SUBUNIT:Interacts with TRIM3.||INTERACTION:P04156:PRNP; NbExp=1; IntAct=EBI-2602680, EBI-977302;||SUBCELLULAR LOCATION:Cytoplasm, cytosol. Early endosome membrane. Note=Localizes to early endosome membrane in absence of Lys-87 monoubiquitination. Localizes to cytosol when monoubiquitinated.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9HCC9-1; Sequence=Displayed; Name=2; IsoId=Q9HCC9-2; Sequence=VSP 037616; Note=No experimental confirmation available; Name=3; IsoId=Q9HCC9-3; Sequence=VSP 037615; Note=No experimental confirmation available; Name=4; IsoId=Q9HCC9-4; Sequence=VSP 037615, VSP 037616; Note=No experimental confirmation available; Name=5; IsoId=Q9HCC9-5; Sequence=VSP 037614; Note=No experimental confirmation available;||DOMAIN:The FYVE-type zinc finger mediates the

Subcellular localization

Cytoplasm, cytosol.Early endosome membrane.

Gene name

zinc finger, FYVE domain containing 28

Protein sequence

MMNRFRKWLYKPKRSDPQLLARFYYADEELNQVAAELDSL DGRKDPQRCTLLVSQFRSCQDNVLNIINQIMDECIPQDR APRDFCVKFPEEIRHDNLAGQLWFGAECLAAGSIIMNRE LESMAMRPLAKELTRSLEDVRGALRDQALRDLNTYTEKM REALRHFDVLFAEFELSYVSAMVPVKSPREYYVQQEVIV LFCETVERALDFGYLTQDMIDDYEPALMFSIPRLAIVCG LVVYADGPLNLDRKVEDMSELFRPFHTLLRKIRDLLQTL TEEELHTLERNLCISQDVEFPIRADVQGPAALAPALSAP LPPEGPLSAKAKDPDAELACSMQYDDQELEQLSRMVHRA GDEMSSLLSPPIACQSPAHRPGAEGSPGGEASPGRPRLR SGSDEEERVFFMDDVEGTAEALARPESPAGPFGWAGSTW ADPQEKGQGGPGGAAGISLPASEKEEDLSNNNLEAEGTD GASLAGTSSCSCLDSRLHLDGWEVGADDAETAEMIAHRT GGMKLSATVIFNPKSPTSLDSAVATQEAASEPVAEGMDG GPHKLSTGATNCLLHSCVCCGSCGDSREDVVERLREKCS PGGVIGASYAAGLAKASDRAPERQEEAPPPSEDASNGRE PKAPTSDKCLPHTSGSQVDTASGLQGEAGVAGQQEPEAR ELHAGSPSAHEAPQALSGSSSSTAGSCSSDKMGPEAAPA ATHAAPQATREKIRSRFHGSHDLIHRLFVCISGVADQLQ TNYASDLRSILKTLFEVMATKPETDDKEKLRKVTQTLRS AALEDCALCQETLSSSELAAKTRDGDFEDPPEWVPDEAC GFCTACKAPFTVIRRKHHCRSCGKIFCSRCSSHSAPLPR YGQVKPVRVCTHCYMFHVTPFYSDKAGL

Database cross reference

RefSeq Protein accession:NP_001166127
RefSeq Protein gi:289547645

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005829;C:cytosol;IDA:UniProtKB. GO:0031901;C:early endosome membrane;IDA:UniProtKB.

GO-F

GO:0032266;F:phosphatidylinositol-3-phosphate binding;IDA:UniProtKB. GO:0005515;F:protein binding;IPI:UniProtKB. GO:0008270;F:zinc ion binding;IEA:InterPro.

GO-P

GO:0007175;P:negative regulation of epidermal growth factor receptor activity;IMP:UniProtKB.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr26637

UBIQUITINATION

87

K

PhosphoSitePlus

7250588

HTP

LTP

N

HuLPr26637

PHOSPHORYLATION

870

T

PhosphoSitePlus

13211300

HTP

N

HuLPr26637

PHOSPHORYLATION

586

S

PhosphoSitePlus

13211301

LTP

N

Internalization_of_ErbB1