HuLPr26649

Uniprot ID

LTOR3_HUMAN

Uniprot Acc

Q9UHA4;B2R4A1;Q9H364;

Protein name

Ragulator complex protein LAMTOR3

Comment

FUNCTION:Regulator of the TOR pathway, a signaling cascade that promotes cell growth in response to growth factors, energy levels, and amino acids. As part of the Ragulator complex, recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.||SUBUNIT:Interacts with MAP2K1 and MAPK2. Interacts with MORG1 (By similarity). Part of the Ragulator complex composed of LAMTOR1, LAMTOR2 and LAMTOR3. Interacts with LAMTOR1; the interaction is direct.||INTERACTION:Q9JHS3:Robld3 (xeno); NbExp=1; IntAct=EBI-1038192, EBI-1038198;||SUBCELLULAR LOCATION:Late endosome membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).||SIMILARITY:Belongs to the LAMTOR3 family.

Subcellular localization

Late endosome membrane;Peripheral membrane protein;Cytoplasmic side(By similarity).

Gene name

late endosomal/lysosomal adaptor, MAPK and MTOR activator 3

Protein sequence

MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDNA PEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQ VVQFNRLPLVVSFIASSSANTGLIVSLEKELAPLFEELR QVVEVS

Database cross reference

RefSeq Protein accession:NP_068805
RefSeq Protein gi:11496277

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0071986;C:Ragulator complex;IDA:UniProtKB.

GO-F

GO:0005515;F:protein binding;IPI:IntAct.

GO-P

GO:0034613;P:cellular protein localization;IMP:UniProtKB. GO:0071230;P:cellular response to amino acid stimulus;IMP:UniProtKB. GO:0032008;P:positive regulation of TOR signaling cascade;IMP:UniProtKB.

EGF/MAPK