HuLPr26813

Uniprot ID

MAGC2_HUMAN

Uniprot Acc

Q9UBF1;Q5JZ00;Q96D45;Q9P1M6;Q9P1M7;

Protein name

Melanoma-associated antigen C2

Comment

SUBCELLULAR LOCATION:Cytoplasm. Nucleus. Note=Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma.||TISSUE SPECIFICITY:Not expressed in normal tissues, except in germ cells in the seminiferous tubules and in Purkinje cells of the cerebellum. Expressed in various tumors, including melanoma, lymphoma, as well as pancreatic cancer, mammary gland cancer, non- small cell lung cancer and liver cancer. In hepatocellular carcinoma, there is a inverse correlation between tumor differentiation and protein expression, i.e. the lower the differentiation, the higher percentage of expression.||DEVELOPMENTAL STAGE:Strongly expressed in spermatogonia and primary spermatocytes. At later stages of maturation, expression gradually decreases and becomes undetectable in mature spermatids.||SIMILARITY:Contains 1 MAGE domain.

Subcellular localization

Cytoplasm.Nucleus.

Gene name

melanoma antigen family C, 2

Protein sequence

MPPVPGVPFRNVDNDSPTSVELEDWVDAQHPTDEEEEEAS SASSTLYLVFSPSSFSTSSSLILGGPEEEEVPSGVIPNL TESIPSSPPQGPPQGPSQSPLSSCCSSFSWSSFSEESSS QKGEDTGTCQGLPDSESSFTYTLDEKVAELVEFLLLKYE AEEPVTEAEMLMIVIKYKDYFPVILKRAREFMELLFGLA LIEVGPDHFCVFANTVGLTDEGSDDEGMPENSLLIIILS VIFIKGNCASEEVIWEVLNAVGVYAGREHFVYGEPRELL TKVWVQGHYLEYREVPHSSPPYYEFLWGPRAHSESIKKK VLEFLAKLNNTVPSSFPSWYKDALKDVEERVQATIDTAD DATVMASESLSVMSSNVSFSE

Database cross reference

RefSeq Protein accession:NP_057333
RefSeq Protein gi:7706605

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005737;C:cytoplasm;IDA:UniProtKB. GO:0005634;C:nucleus;IDA:UniProtKB.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr26813

PHOSPHORYLATION

259

Y

PhosphoSitePlus

486456

LTP

N