Protein basic information
| LiverAtlas Protein ID |
HuLPr26985 |
|
Uniprot ID |
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Uniprot Acc |
Q9P1T7;Q9P1T6; |
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Protein name |
MyoD family inhibitor domain-containing protein |
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Comment |
FUNCTION:Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin- beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.||SUBUNIT:Interacts with HAND1; leading to sequester HAND1 into the nucleolus and prevent its activity. Interacts with ZIC2 (By similarity). The C-terminus interacts with HIV-1 Tat and Rev, AXIN1, the histidine-rich region of CCNT1/cyclin-T and weakly wit |
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Subcellular localization |
Isoform 1:Nucleus, nucleolus. |
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Gene name |
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Protein sequence
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MSGAGEALAPGPVGPQRVAEAGGGQLGSTAQGKCDKDNTE KDITQATNSHFTHGEMQDQSIWGNPSDGELIRTQPQRLP QLQTSAQVPSGEEIGKIKNGHTGLSNGNGIHHGAKHGSA DNRKLSAPVSQKMHRKIQSSLSVNSDISKKSKVNAVFSQ KTGSSPEDCCVHCILACLFCEFLTLCNIVLGQASCGICT SEACCCCCGDEMGDDCNCPCDMDCGIMDACCESSDCLEI CMECCGICFPS |
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Database cross reference |
RefSeq Protein accession:NP_001159817
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IDA:UniProtKB. GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005730;C:nucleolus;IDA:UniProtKB. GO:0005730;C:nucleolus;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IDA:UniProtKB. |
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GO-F |
GO:0030332;F:cyclin binding;IPI:UniProtKB. GO:0030957;F:Tat protein binding;IDA:UniProtKB. GO:0016564;F:transcription repressor activity;ISS:UniProtKB. |
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GO-P |
GO:0007257;P:activation of JUN kinase activity;IPI:UniProtKB. GO:0044419;P:interspecies interaction between organisms;IEA:UniProtKB-KW. GO:0042308;P:negative regulation of protein import into nucleus;ISS:UniProtKB. GO:0045893;P:positive regulation of tr |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr26985 |
PHOSPHORYLATION |
249 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr26985 |
PHOSPHORYLATION |
252 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr26985 |
PHOSPHORYLATION |
140 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr26985 |
PHOSPHORYLATION |
143 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr26985 |
PHOSPHORYLATION |
146 |
S |
PhosphoSitePlus |
LTP |
N |
|
Pathway
| Pathway name |
