Protein basic information
| LiverAtlas Protein ID |
HuLPr27066 |
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Uniprot ID |
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Uniprot Acc |
P08581;O60366;Q12875;Q9UDX7;Q9UPL8; |
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Protein name |
Hepatocyte growth factor receptor |
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Comment |
FUNCTION:Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.||CATALYTIC ACTIVITY:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.||SUBUNIT:Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10.||INTERACTION:P00533:EGFR; NbExp=1; IntAct=EBI-1039152, EBI-297353; P14210:HGF; NbExp=2; IntAct=EBI-10 |
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Subcellular localization |
Membrane;Single-pass type I membrane protein. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMK YQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQ KVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINM ALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSE VHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFF VGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYI DVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTF HTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEV FNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPD SAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYG PNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLF MGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSR SGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGK KITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVR SEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGW DFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCT VGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISP KYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVS NSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDP IVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHE AGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAF FMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLE IKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPN DLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAG VVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVH TPHLDRLVSARSVSPTTEMVSNES |
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Database cross reference |
RefSeq Protein accession:NP_000236
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0009925;C:basal plasma membrane;IDA:MGI. GO:0005887;C:integral to plasma membrane;TAS:ProtInc. |
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GO-F |
GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0005008;F:hepatocyte growth factor receptor activity;TAS:ProtInc. GO:0005515;F:protein binding;IPI:UniProtKB. |
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GO-P |
GO:0007411;P:axon guidance;TAS:Reactome. GO:0008283;P:cell proliferation;TAS:ProtInc. GO:0006468;P:protein phosphorylation;IEA:InterPro. |