Protein basic information
| LiverAtlas Protein ID |
HuLPr27146 |
|
Uniprot ID |
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Uniprot Acc |
Q96AX9;A2AGM5;A2AGM6;B3KV93;B3KVF4;Q7Z437;Q8IY62;Q8N786;Q8N897;Q8N8R2;Q8N911;Q8NB36;Q8NCY1;Q8NG59;Q8NG60;Q8NG61;Q8NI59;Q8WYN1; |
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Protein name |
E3 ubiquitin-protein ligase MIB2 |
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Comment |
FUNCTION:E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors (By similarity).||PATHWAY:Protein modification; protein ubiquitination.||SUBUNIT:Interacts with actin monomer.||SUBCELLULAR LOCATION:Cytoplasm. Endosome. Note=Colocalizes with endosomal compartments.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=9; Name=1; IsoId=Q96AX9-1; Sequence=Displayed; Name=2; Synonyms=Alpha; IsoId=Q96AX9-2; Sequence=VSP 014392; Name=3; Synonyms=Gamma; IsoId=Q96AX9-3; Sequence=VSP 014395; Name=4; Synonyms=Beta; IsoId=Q96AX9-4; Sequence=VSP 014393; Name=5; IsoId=Q96AX9-5; Sequence=VSP 014396; Note=No experimental confirmation available; Name=7; IsoId=Q96AX9-7; Sequence=VSP 035508; Name=8; IsoId=Q96AX9-8; Sequence=VSP 035509, VSP 035511, VSP 035512; Note=No |
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Subcellular localization |
Cytoplasm.Endosome. |
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Gene name |
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Protein sequence
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MGWKPSEARGQSQSFQASGLQPRSLKAARRATGRPDRSRA ARPTMDPSAHRSRAAPPNMDPDPQAGVQVGMRVVRGVDW KWGQQDGGEGGVGTVVELGRHGSPSTPDRTVVVQWDQGT RTNYRAGYQGAHDLLLYDNAQIGVRHPNIICDCCKKHGL RGMRWKCRVCLDYDLCTQCYMHNKHELAHAFDRYETAHS RPVTLSPRQGLPRIPLRGIFQGAKVVRGPDWEWGSQDGG EGKPGRVVDIRGWDVETGRSVASVTWADGTTNVYRVGHK GKVDLKCVGEAAGGFYYKDHLPRLGKPAELQRRVSADSQ PFQHGDKVKCLLDTDVLREMQEGHGGWNPRMAEFIGQTG TVHRITDRGDVRVQFNHETRWTFHPGALTKHHSFWVGDV VRVIGDLDTVKRLQAGHGEWTDDMAPALGRVGKVVKVFG DGNLRVAVAGQRWTFSPSCLVAYRPEEDANLDVAERARE NKSSLSVALDKLRAQKSDPEHPGRLVVEVALGNAARALD LLRRRPEQVDTKNQGRTALQVAAYLGQVELIRLLLQARA GVDLPDDEGNTALHYAALGNQPEATRVLLSAGCRADAIN STQSTALHVAVQRGFLEVVRALCERGCDVNLPDAHSDTP LHSAISAGTGASGIVEVLTEVPNIDVTATNSQGFTLLHH ASLKGHALAVRKILARARQLVDAKKEDGFTALHLAALNN HREVAQILIREGRCDVNVRNRKLQSPLHLAVQQAHVGLV PLLVDAGCSVNAEDEEGDTALHVALQRHQLLPLVADGAG GDPGPLQLLSRLQASGLPGSAELTVGAAVACFLALEGAD VSYTNHRGRSPLDLAAEGRVLKALQGCAQRFRERQAGGG AAPGPRQTLGTPNTVTNLHVGAAPGPEAAECLVCSELAL LVLFSPCQHRTVCEECARRMKKCIRCQVVVSKKLRPDGS EVASAAPAPGPPRQLVEELQSRYRQMEERITCPICIDSH IRLVFQCGHGACAPCGSALSACPI |
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Database cross reference |
RefSeq Protein accession:NP_001164157
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005768;C:endosome;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0003779;F:actin binding;IEA:UniProtKB-KW. GO:0004871;F:signal transducer activity;IMP:UniProtKB. GO:0004842;F:ubiquitin-protein ligase activity;IEA:InterPro. GO:0008270;F:zinc ion binding;IEA:InterPro. |
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GO-P |
GO:0007219;P:Notch signaling pathway;IEA:UniProtKB-KW. GO:0043123;P:positive regulation of I-kappaB kinase/NF-kappaB cascade;IMP:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr27146 |
PHOSPHORYLATION |
200 |
T |
Phospho-ELM |
HTP |
N |
 
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|
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HuLPr27146 |
PHOSPHORYLATION |
202 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr27146 |
PHOSPHORYLATION |
200 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27146 |
PHOSPHORYLATION |
202 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27146 |
PHOSPHORYLATION |
312 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr27146 |
PHOSPHORYLATION |
309 |
S |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name |
