Protein basic information
| LiverAtlas Protein ID |
HuLPr27148 |
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Uniprot ID |
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Uniprot Acc |
Q29983;A8KQR0;A9LRW5;A9QVE0;B1VJF1;O60917;O60918;O60919;O60920;O60933;O77956;O78150;O78151;O78152;O78153;O97987;O97988;O97989;O97990;O97991;O97992;O97993;O97994;O97995;O98234;O98235;O98236;O98237;O98238;P79506;P79507;P79508;P79509;P79510;P79511;P79512;P795 |
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Protein name |
MHC class I polypeptide-related sequence A |
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Comment |
FUNCTION:Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T- cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.||SUBUNIT:Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICA while HCST acts as an adapter molecule which enables signal transduction. Interacts with PDIA6 on the surface of tumor cells, leading to disulfide bond reduction which is required for release of MICA from tumor cells.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Expressed on the cell surface in gastric epithelium, endothelial cells and fibroblasts and in the cytoplasm in keratinocytes and monocytes. Infection with human adenovirus 5 suppresses cell surface expression due to the adenoviral E3-19K protein which causes reten |
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Subcellular localization |
Cell membrane;Single-pass type I membrane protein.Cytoplasm. |
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Gene name |
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Protein sequence
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MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGS VQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGN KTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRV CEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSR AQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLK SGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNI TLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQ GEEQRFTCYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVS AVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQH PVGTSDHRDATQLGFQPLMSDLGSTGSTEGA |
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Database cross reference |
RefSeq Protein accession:NP_000238
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0009986;C:cell surface;IDA:BHF-UCL. GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0005615;C:extracellular space;IDA:BHF-UCL. GO:0005887;C:integral to plasma membrane;IDA:UniProtKB. GO:0042612;C:MHC class I protein complex;IEA:InterPro. |
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GO-F |
GO:0046703;F:natural killer cell lectin-like receptor binding;IDA:UniProtKB. |
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GO-P |
GO:0019882;P:antigen processing and presentation;IEA:InterPro. GO:0019835;P:cytolysis;IEA:UniProtKB-KW. GO:0042742;P:defense response to bacterium;IDA:UniProtKB. GO:0051607;P:defense response to virus;IDA:UniProtKB. GO:0046629;P:gamma-delta T cell acti |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr27148 |
PHOSPHORYLATION |
194 |
Y |
PhosphoSitePlus |
LTP |
N |
 
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|
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HuLPr27148 |
PHOSPHORYLATION |
197 |
S |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name |
