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Protein basic information

LiverAtlas Protein ID

HuLPr27154

Uniprot ID

MICU1_HUMAN

Uniprot Acc

Q9BPX6;A8MV96;B3KN20;B4DJH9;B4DPI1;B5MBY3;D3YTJ3;O75785;Q9H9N6;Q9UFX0;

Protein name

Calcium uptake protein 1, mitochondrial

Comment

FUNCTION:Key regulator of mitochondrial calcium uptake required for calcium entry into mitochondrion. May act as a calcium sensor via its EF-hand domains, gating the activity of a calcium channel partner. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG.||SUBCELLULAR LOCATION:Mitochondrion inner membrane; Single-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9BPX6-1; Sequence=Displayed; Name=2; IsoId=Q9BPX6-2; Sequence=VSP 031980, VSP 031981; Note=No experimental confirmation available; Name=3; IsoId=Q9BPX6-3; Sequence=VSP 031979; Note=No experimental confirmation available; Name=4; IsoId=Q9BPX6-4; Sequence=VSP 039890, VSP 039891; Note=No experimental confirmation available; Name=5; IsoId=Q9BPX6-5; Sequence=VSP 039890, VSP 039892; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expressed in epithelial cell line. Strongly expressed in epidermal keratinocyt

Subcellular localization

Mitochondrion inner membrane;Single-pass membrane protein.

Gene name

calcium binding atopy-related autoantigen 1

Protein sequence

MFRLNSLSALAELAVGSRWYHGGSQPIQIRRRLMMVAFLG ASAVTASTGLLWKRAHAESPPCVDNLKSDIGDKGKNKDE GDVCNHEKKTADLAPHPEEKKKKRSGFRDRKVMEYENRI RAYSTPDKIFRYFATLKVISEPGEAEVFMTPEDFVRSIT PNEKQPEHLGLDQYIIKRFDGKKISQEREKFADEGSIFY TLGECGLISFSDYIFLTTVLSTPQRNFEIAFKMFDLNGD GEVDMEEFEQVQSIIRSQTSMGMRHRDRPTTGNTLKSGL CSALTTYFFGADLKGKLTIKNFLEFQRKLQHDVLKLEFE RHDPVDGRITERQFGGMLLAYSGVQSKKLTAMQRQLKKH FKEGKGLTFQEVENFFTFLKNINDVDTALSFYHMAGASL DKVTMQQVARTVAKVELSDHVCDVVFALFDCDGNGELSN KEFVSIMKQRLMRGLEKPKDMGFTRLMQAMWKCAQETAWDFALPKQ

Database cross reference

RefSeq Protein accession:NP_001182447
RefSeq Protein gi:306922382

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005743;C:mitochondrial inner membrane;IDA:UniProtKB.

GO-F

GO:0005509;F:calcium ion binding;IEA:InterPro.

GO-P

GO:0070509;P:calcium ion import;IDA:UniProtKB. GO:0006952;P:defense response;TAS:ProtInc. GO:0051561;P:elevation of mitochondrial calcium ion concentration;IMP:UniProtKB.