Protein basic information
| LiverAtlas Protein ID |
HuLPr27167 |
|
Uniprot ID |
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Uniprot Acc |
Q8IUF8;D3DN35;Q6AHW4;Q6SKS0;Q8IU69;Q8IUF6;Q8IUF7;Q96C17;Q96KB0; |
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Protein name |
MYC-induced nuclear antigen |
|
Comment |
FUNCTION:Involved in cellular proliferation. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles.||SUBCELLULAR LOCATION:Nucleus. Nucleus, nucleolus.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8IUF8-1; Sequence=Displayed; Name=2; IsoId=Q8IUF8-2; Sequence=VSP 052589, VSP 052590; Name=3; IsoId=Q8IUF8-3; Sequence=VSP 052587, VSP 052588; Name=4; IsoId=Q8IUF8-4; Sequence=VSP 038373;||TISSUE SPECIFICITY:Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines.||INDUCTION:Up-regulated in response to MYC, in alveolar macrophages from coal miners and in si |
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Subcellular localization |
Nucleus.Nucleus, nucleolus. |
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Gene name |
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Protein sequence
|
MPKKAKPTGSGKEEGPAPCKQMKLEAAGGPSALNFDSPSS LFESLISPIKTETFFKEFWEQKPLLIQRDDPALATYYGS LFKLTDLKSLCSRGMYYGRDVNVCRCVNGKKKVLNKDGK AHFLQLRKDFDQKRATIQFHQPQRFKDELWRIQEKLECY FGSLVGSNVYITPAGSQGLPPHYDDVEVFILQLEGEKHW RLYHPTVPLAREYSVEAEERIGRPVHEFMLKPGDLLYFP RGTIHQADTPAGLAHSTHVTISTYQNNSWGDFLLDTISG LVFDTAKEDVELRTGIPRQLLLQVESTTVATRRLSGFLR TLADRLEGTKELLSSDMKKDFIMHRLPPYSAGDGAELST PGGKLPRLDSVVRLQFKDHIVLTVLPDQDQSDEAQEKMV YIYHSLKNSRETHMMGNEEETEFHGLRFPLSHLDALKQI WNSPAISVKDLKLTTDEEKESLVLSLWTECLIQVV |
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Database cross reference |
RefSeq Protein accession:NP_001035998
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IDA:HPA. GO:0005730;C:nucleolus;IDA:HPA. |
|
GO-P |
GO:0042254;P:ribosome biogenesis;IEA:UniProtKB-KW. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr27167 |
ACETYLATION |
20 |
K |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr27167 |
PHOSPHORYLATION |
309 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27167 |
PHOSPHORYLATION |
76 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27167 |
PHOSPHORYLATION |
77 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27167 |
PHOSPHORYLATION |
95 |
Y |
PhosphoSitePlus |
LTP |
N |
|
Pathway
| Pathway name |
