Protein basic information
| LiverAtlas Protein ID |
HuLPr27169 |
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Uniprot ID |
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Uniprot Acc |
Q9UNW1;O95172;O95286;Q59EJ2;Q9UGA3; |
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Protein name |
Multiple inositol polyphosphate phosphatase 1 |
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Comment |
FUNCTION:Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6) (By similarity). May play a role in bone development (endochondral ossification).||CATALYTIC ACTIVITY:Myo-inositol hexakisphosphate + H(2)O = myo- inositol pentakisphosphate (mixed isomers) + phosphate.||SUBCELLULAR LOCATION:Endoplasmic reticulum lumen (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9UNW1-1; Sequence=Displayed; Name=2; IsoId=Q9UNW1-2; Sequence=VSP 014552, VSP 014555; Note=No experimental confirmation available; Name=3; IsoId=Q9UNW1-3; Sequence=VSP 014553, VSP 014554; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Widely expressed with highest levels in kidney, liver and placenta.||DISEASE:Note=Defects in MINPP1 may be involved in follicular thyroid tumors development.||SEQUENCE CAUTION:Sequence=BAD93056.1; Type=E |
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Subcellular localization |
Endoplasmic reticulum lumen(By similarity). |
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Gene name |
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Protein sequence
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MLRAPGCLLRTSVAPAAALAAALLSSLARCSLLEPRDPVA SSLSPYFGTKTRYEDVNPVLLSGPEAPWRDPELLEGTCT PVQLVALIRHGTRYPTVKQIRKLRQLHGLLQARGSRDGG ASSTGSRDLGAALADWPLWYADWMDGQLVEKGRQDMRQL ALRLASLFPALFSRENYGRLRLITSSKHRCMDSSAAFLQ GLWQHYHPGLPPPDVADMEFGPPTVNDKLMRFFDHCEKF LTEVEKNATALYHVEAFKTGPEMQNILKKVAATLQVPVN DLNADLIQVAFFTCSFDLAIKGVKSPWCDVFDIDDAKVL EYLNDLKQYWKRGYGYTINSRSSCTLFQDIFQHLDKAVE QKQRSQPISSPVILQFGHAETLLPLLSLMGYFKDKEPLT AYNYKKQMHRKFRSGLIVPYASNLIFVLYHCENAKTPKE QFRVQMLLNEKVLPLAYSQETVSFYEDLKNHYKDILQSC QTSEECELARANSTSDEL |
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Database cross reference |
RefSeq Protein accession:NP_001171588
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005788;C:endoplasmic reticulum lumen;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0003993;F:acid phosphatase activity;IEA:InterPro. GO:0034417;F:bisphosphoglycerate 3-phosphatase activity;IDA:BHF-UCL. GO:0004446;F:multiple inositol-polyphosphate phosphatase activity;IEA:EC. GO:0008969;F:phosphohistidine phosphatase activity;TAS:Pr |
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GO-P |
GO:0030282;P:bone mineralization;NAS:UniProtKB. GO:0006797;P:polyphosphate metabolic process;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr27169 |
PHOSPHORYLATION |
315 |
Y |
PhosphoSitePlus |
LTP |
N |
 
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Pathway
| Pathway name | |
| Pathway name |
