Protein basic information
| LiverAtlas Protein ID |
HuLPr27241 |
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Uniprot ID |
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Uniprot Acc |
Q495T6;B9DI79;Q495T7;Q495T8;Q5SZS6;Q96PH9; |
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Protein name |
Membrane metallo-endopeptidase-like 1 |
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Comment |
FUNCTION:Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificiy with MME and cleaves peptides at the same amide bond (By similarity).||CATALYTIC ACTIVITY:Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.||COFACTOR:Binds 1 zinc ion per subunit (By similarity).||ENZYME REGULATION:Inhibited by thiorphan and phosphoramidon (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteollytic cleavage also exists (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q495T6-1; Sequence=Displayed; Name=2; IsoId=Q495T6-2; Sequence=VSP 020288, VSP 0202 |
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Subcellular localization |
Membrane;Single-pass type II membrane protein.Secreted. |
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Gene name |
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Protein sequence
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MGKSEGPVGMVESAGRAGQKRPGFLEGGLLLLLLLVTAAL VALGVLYADRRGKQLPRLASRLCFLQEERTFVKRKPRGI PEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQF ACGGWLRRHVIPETNSRYSIFDVLRDELEVILKAVLENS TAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVV GGWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDL FIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVR EAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELET QLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWT LFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDTYS ARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTM VEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVR ELIDKVRTVFVETLDELGWMDEESKKKAQEKAMSIREQI GHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVG AQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPA GILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRN FDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLAD EQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQ LPGLDLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHS PLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW |
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Database cross reference |
RefSeq Protein accession:NP_258428
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0043231;C:intracellular membrane-bounded organelle;IDA:HPA. |
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GO-F |
GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0004222;F:metalloendopeptidase activity;IEA:InterPro. |
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GO-P |
GO:0006508;P:proteolysis;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr27241 |
ACETYLATION |
183 |
K |
PhosphoSitePlus |
HTP |
N |
 
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