HuLPr27291

Uniprot ID

MOES_HUMAN

Uniprot Acc

P26038;

Protein name

Moesin

Comment

FUNCTION:Probably involved in connections of major cytoskeletal structures to the plasma membrane.||SUBUNIT:In resting T-cells, part of a PAG1-SLC9A3R1-MSN complex which is disrupted upon TCR activation (By similarity). Binds SLC9A3R1. Interacts with PPP1R16B.||INTERACTION:P30480:HLA-B; NbExp=1; IntAct=EBI-528768, EBI-1054175; O14745:SLC9A3R1; NbExp=2; IntAct=EBI-528768, EBI-349787;||SUBCELLULAR LOCATION:Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytoskeleton (By similarity). Apical cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=Phosphorylated form is enriched in microvilli- like structures at apical membrane (By similarity). Increased cell membrane localization of both phosphorylated and non- phosphorylated forms seen after thrombin treatment.||TISSUE SPECIFICITY:In all tissues and cultured cells studied

Subcellular localization

Cell membrane;Peripheral membrane protein;Cytoplasmic side(By similarity).Cytoplasm, cytoskeleton(By similarity).Apical cell membrane;Peripheral membrane protein;Cytoplasmic side(By similarity).Cell projection, microvillus membrane;Peripheral membrane protein;Cytoplasmic side(By similarity).

Gene name

moesin

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLR EVWFFGLQYQDTKGFSTWLKLNKKVTAQDVRKESPLLFK FRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCP PETAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRV LEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQ DLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLT PKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRL RINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEK HQKQMERAMLENEKKKREMAEKEKEKIEREKEELMERLK QIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAK ERQEAEEAKEALLQASRDQKKTQEQLALEMAELTARISQ LEMARQKKESEAVEWQQKAQMVQEDLEKTRAELKTAMST PHVAEPAENEQDEQDENGAEASADLRADAMAKDRSEEER TTEAEKNERVQKHLKALTSELANARDESKKTANDMIHAE NMRLGRDKYKTLRQIRQGNTKQRIDEFESM

Database cross reference

RefSeq Protein accession:NP_002435
RefSeq Protein gi:4505257

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

GO:0016324;C:apical plasma membrane;IEA:UniProtKB-SubCell. GO:0005856;C:cytoskeleton;TAS:UniProtKB. GO:0019898;C:extrinsic to membrane;IEA:InterPro. GO:0031528;C:microvillus membrane;IEA:UniProtKB-SubCell. GO:0005730;C:nucleolus;IDA:HPA.

GO-F

GO:0050839;F:cell adhesion molecule binding;IPI:BHF-UCL. GO:0005102;F:receptor binding;IPI:UniProtKB. GO:0005200;F:structural constituent of cytoskeleton;TAS:ProtInc.

GO-P

GO:0007159;P:leukocyte cell-cell adhesion;IEP:BHF-UCL. GO:0050900;P:leukocyte migration;IEP:BHF-UCL. GO:0022614;P:membrane to membrane docking;IEP:BHF-UCL.