HuLPr27399

Uniprot ID

MRP7_HUMAN

Uniprot Acc

Q5T3U5;Q8NHX7;Q9H7N2;Q9NXY3;Q9UF48;

Protein name

Multidrug resistance-associated protein 7

Comment

FUNCTION:ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=57.8 uM for 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius); Vmax=20 pmol/min/mg enzyme toward 17-beta-estradiol 17-(beta-D- glucuronide) (at 37 degrees Celsius);||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Mrp7; IsoId=Q5T3U5-1; Sequence=Displayed; Name=2; Synonyms=Mrp7A; IsoId=Q5T3U5-2; Sequence=VSP 021078, VSP 021079, VSP 021080;||TISSUE SPECIFICITY:Isoform 1 is specifically expressed in spleen. Isoform 2 is more widely expressed.||SIMILARITY:Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.||SIMILARITY:Contains 2 ABC transmembrane type-1 domains.||SIMILARITY:Contains 2 ABC transporter domains.||SEQUENCE CAUTION:Sequence=BAA92227

Subcellular localization

Cell membrane;Multi-pass membrane protein.

Gene name

ATP-binding cassette, sub-family C (CFTR/MRP), member 10

Protein sequence

MERLLAQLCGSSAAWPLPLWEGDTTGHCFTQLVLSALPHA LLAVLSACYLGTPRSPDYILPCSPGWRLRLAASFLLSVF PLLDLLPVALPPGAGPGPIGLEVLAGCVAAVAWISHSLA LWVLAHSPHGHSRGPLALALVALLPAPALVLTVLWHCQR GTLLPPLLPGPMARLCLLILQLAALLAYALGWAAPGGPR EPWAQEPLLPEDQEPEVAEDGESWLSRFSYAWLAPLLAR GACGELRQPQDICRLPHRLQPTYLARVFQAHWQEGARLW RALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFL EEGQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVT LQARGAVLNILYCKALQLGPSRPPTGEALNLLGTDSERL LNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILA LLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGI RVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVY LWAALPVVISIVIFITYVLMGHQLTATKVFTALALVRML ILPLNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYY SPDPPAEPSTVLELHGALFSWDPVGTSLETFISHLEVKK GMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSK GFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACA LNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQ EKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLC THRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPK AWAENGQESDSATAQSVQNPEKTKEGLEEEQSTSGRLLQ EESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQAT RNAADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQ LLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAG VNSLCTLLRAVLFAAGTLQAAATL

Database cross reference

RefSeq Protein accession:NP_001185863
RefSeq Protein gi:312176403

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0042626;F:ATPase activity, coupled to transmembrane movement of substances;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr27399

PHOSPHORYLATION

463

T

Phospho-ELM

41422

HTP

N

HuLPr27399

PHOSPHORYLATION

467

S

Phospho-ELM

41423

HTP

N

Vinblastine_Pathway

Vincristine_Pathway

Vindesine_Pathway

Vinorelbine_Pathway