HuLPr27503

Uniprot ID

MTNA_HUMAN

Uniprot Acc

Q9BV20;Q8NDC9;

Protein name

Methylthioribose-1-phosphate isomerase

Comment

FUNCTION:Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover.||CATALYTIC ACTIVITY:S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate.||PATHWAY:Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate:step 1/6.||INTERACTION:Self; NbExp=3; IntAct=EBI-747381, EBI-747381;||SUBCELLULAR LOCATION:Nucleus. Cytoplasm. Cell projection. Note=Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BV20-1; Sequence=Displayed; Name=2; IsoId=Q9BV20-2; Sequence=VSP 030935;||INDUCTION:By RhoA

Subcellular localization

Nucleus.Cytoplasm.Cell projection.

Gene name

methylthioribose-1-phosphate isomerase homolog (S. cerevisiae)

Protein sequence

MTLEAIRYSRGSLQILDQLLLPKQSRYEAVGSVHQAWEAI RAMKVRGAPAIALVGCLSLAVELQAGAGGPGLAALVAFV RDKLSFLVTARPTAVNMARAARDLADVAAREAEREGATE EAVRERVICCTEDMLEKDLRDNRSIGDLGARHLLERVAP SGGKVTVLTHCNTGALATAGYGTALGVIRSLHSLGRLEH AFCTETRPYNQGARLTAFELVYEQIPATLITDSMVAAAM AHRGVSAVVVGADRVVANGDTANKVGTYQLAIVAKHHGI PFYVAAPSSSCDLRLETGKEIIIEERPGQELTDVNGVRI AAPGIGVWNPAFDVTPHDLITGGIITELGVFAPEELRTA LTTTISSRDGTLDGPQM

Database cross reference

RefSeq Protein accession:NP_001026897
RefSeq Protein gi:72534748

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Fetal Liver;Human Liver Organelles;

GO:0042995;C:cell projection;IEA:UniProtKB-SubCell. GO:0005737;C:cytoplasm;ISS:RefGenome. GO:0005634;C:nucleus;ISS:RefGenome.

GO-F

GO:0042802;F:identical protein binding;IPI:IntAct. GO:0046523;F:S-methyl-5-thioribose-1-phosphate isomerase activity;ISS:RefGenome.

GO-P

GO:0019509;P:L-methionine salvage from methylthioadenosine;ISS:RefGenome.