Protein basic information
LiverAtlas Protein ID |
HuLPr27507 |
Uniprot ID |
|
Uniprot Acc |
P42345;Q4LE76;Q5TER1;Q6LE87;Q96QG3;Q9Y4I3; |
Protein name |
Serine/threonine-protein kinase mTOR |
Comment |
FUNCTION:Kinase subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up- regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-421', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Phosphorylates MAF1 leading to attenuation of its RNA polymerase III-r |
Subcellular localization |
Endoplasmic reticulum membrane;Peripheral membrane protein;Cytoplasmic side.Golgi apparatus membrane;Peripheral membrane protein;Cytoplasmic side.Mitochondrion outer membrane;Peripheral membrane protein;Cytoplasmic side.Lysosome.Cytoplasm(By similarity).Nucleus, PML body(By similarity). |
Gene name |
|
Protein sequence
|
MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKA AKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSD ANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSN DPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLG ADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFV AVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYR HTFEEAEKGFDETLAKEKGMNRDDRIHGALLILNELVRI SSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHI TPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPA KSTLVESRCCRDLMEEKFDQVCQWVLKCRNSKNSLIQMT ILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKER TAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFA HKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPM LAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVL MHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLAL RTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAART CSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGI TDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQ VFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELE HSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALIL KLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDEL FIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYR KYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYK HKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVN MGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAIT FIFKSLGLKCVQFLPQVMPTFLNV |
Database cross reference |
RefSeq Protein accession:NP_004949
|
Liver relevance
HLPP validation |
Yes/No |
Yes |
Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
GO-C |
GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0005764;C:lysosome;IDA:UniProtKB. GO:0005741;C:mitochondrial outer membrane;IEA:UniProtKB-SubCell. GO:0005942;C:phosphatidylinosito |
GO-F |
GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0051219;F:phosphoprotein binding;IPI:UniProtKB. GO:0004674;F:protein serine/threonine kinase activity;IDA:UniProtKB. |
GO-P |
GO:0016049;P:cell growth;TAS:UniProtKB. GO:0071456;P:cellular response to hypoxia;ISS:UniProtKB. GO:0008286;P:insulin receptor signaling pathway;TAS:Reactome. GO:0048011;P:nerve growth factor receptor signaling pathway;TAS:Reactome. GO:0018105;P:peptid |
Post-translational modification
LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
HuLPr27507 |
PHOSPHORYLATION |
2446 |
T |
Phospho-ELM |
LTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
2448 |
S |
Phospho-ELM |
LTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
2481 |
S |
Phospho-ELM |
HTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
1162 |
T |
Phospho-ELM |
HTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
1262 |
T |
Phospho-ELM |
HTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
2474 |
T |
Phospho-ELM |
HTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
2478 |
S |
Phospho-ELM |
HTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
2454 |
S |
PhosphoSitePlus |
LTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
1166 |
S |
PhosphoSitePlus |
LTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
1870 |
T |
PhosphoSitePlus |
LTP |
N |
||
HuLPr27507 |
ACETYLATION |
1218 |
K |
PhosphoSitePlus |
HTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
567 |
S |
PhosphoSitePlus |
LTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
1261 |
S |
PhosphoSitePlus |
LTP HTP |
yes |
||
HuLPr27507 |
PHOSPHORYLATION |
2473 |
T |
PhosphoSitePlus |
LTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
2474 |
T |
PhosphoSitePlus |
LTP HTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
2478 |
S |
PhosphoSitePlus |
LTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
1874 |
S |
PhosphoSitePlus |
LTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
1876 |
T |
PhosphoSitePlus |
LTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
1880 |
Y |
PhosphoSitePlus |
LTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
2481 |
S |
PhosphoSitePlus |
LTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
1162 |
T |
PhosphoSitePlus |
HTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
2448 |
S |
PhosphoSitePlus |
LTP |
N |
||
HuLPr27507 |
PHOSPHORYLATION |
2446 |
T |
PhosphoSitePlus |
LTP |
N |
Pathway
Pathway name | |
Pathway name | |
Pathway name | |
Pathway name | |
Pathway name | |
Pathway name | |
Pathway name | |
Pathway name | |
Pathway name | |
Pathway name | |
Pathway name | |
Pathway name |
Signaling_events_mediated_by_Hepatocyte_Growth_Factor_Receptor_(c-Met) |
Pathway name | |
Pathway name | |
Pathway name | |
Pathway name |