Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr27507

Uniprot ID

MTOR_HUMAN

Uniprot Acc

P42345;Q4LE76;Q5TER1;Q6LE87;Q96QG3;Q9Y4I3;

Protein name

Serine/threonine-protein kinase mTOR

Comment

FUNCTION:Kinase subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Growth factor-stimulated mTORC1 activation involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino-acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up- regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-421', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Phosphorylates MAF1 leading to attenuation of its RNA polymerase III-r

Subcellular localization

Endoplasmic reticulum membrane;Peripheral membrane protein;Cytoplasmic side.Golgi apparatus membrane;Peripheral membrane protein;Cytoplasmic side.Mitochondrion outer membrane;Peripheral membrane protein;Cytoplasmic side.Lysosome.Cytoplasm(By similarity).Nucleus, PML body(By similarity).

Gene name

mechanistic target of rapamycin (serine/threonine kinase)

Protein sequence

MLGTGPAAATTAATTSSNVSVLQQFASGLKSRNEETRAKA AKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSD ANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSN DPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLG ADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFV AVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYR HTFEEAEKGFDETLAKEKGMNRDDRIHGALLILNELVRI SSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHI TPFTSFQAVQPQQSNALVGLLGYSSHQGLMGFGTSPSPA KSTLVESRCCRDLMEEKFDQVCQWVLKCRNSKNSLIQMT ILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKER TAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFA HKRQKAMQVDATVFTCISMLARAMGPGIQQDIKELLEPM LAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVL MHKPLRHPGMPKGLAHQLASPGLTTLPEASDVGSITLAL RTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAART CSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGI TDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQ VFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELE HSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALIL KLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDEL FIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYR KYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYK HKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVN MGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAIT FIFKSLGLKCVQFLPQVMPTFLNV

Database cross reference

RefSeq Protein accession:NP_004949
RefSeq Protein gi:4826730

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0005764;C:lysosome;IDA:UniProtKB. GO:0005741;C:mitochondrial outer membrane;IEA:UniProtKB-SubCell. GO:0005942;C:phosphatidylinosito

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0051219;F:phosphoprotein binding;IPI:UniProtKB. GO:0004674;F:protein serine/threonine kinase activity;IDA:UniProtKB.

GO-P

GO:0016049;P:cell growth;TAS:UniProtKB. GO:0071456;P:cellular response to hypoxia;ISS:UniProtKB. GO:0008286;P:insulin receptor signaling pathway;TAS:Reactome. GO:0048011;P:nerve growth factor receptor signaling pathway;TAS:Reactome. GO:0018105;P:peptid

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr27507

PHOSPHORYLATION

2446

T

Phospho-ELM

2310

LTP

N

HuLPr27507

PHOSPHORYLATION

2448

S

Phospho-ELM

2311

LTP

N

HuLPr27507

PHOSPHORYLATION

2481

S

Phospho-ELM

2309

HTP

N

HuLPr27507

PHOSPHORYLATION

1162

T

Phospho-ELM

33426

HTP

N

HuLPr27507

PHOSPHORYLATION

1262

T

Phospho-ELM

33427

HTP

N

HuLPr27507

PHOSPHORYLATION

2474

T

Phospho-ELM

33428

HTP

N

HuLPr27507

PHOSPHORYLATION

2478

S

Phospho-ELM

33425

HTP

N

HuLPr27507

PHOSPHORYLATION

2454

S

PhosphoSitePlus

4780698

LTP

N

HuLPr27507

PHOSPHORYLATION

1166

S

PhosphoSitePlus

18012488

LTP

N

HuLPr27507

PHOSPHORYLATION

1870

T

PhosphoSitePlus

5861819

LTP

N

HuLPr27507

ACETYLATION

1218

K

PhosphoSitePlus

11321025

HTP

N

HuLPr27507

PHOSPHORYLATION

567

S

PhosphoSitePlus

458284

LTP

N

HuLPr27507

PHOSPHORYLATION

1261

S

PhosphoSitePlus

458285

LTP

HTP

yes

HuLPr27507

PHOSPHORYLATION

2473

T

PhosphoSitePlus

458288

LTP

N

HuLPr27507

PHOSPHORYLATION

2474

T

PhosphoSitePlus

458289

LTP

HTP

N

HuLPr27507

PHOSPHORYLATION

2478

S

PhosphoSitePlus

458290

LTP

N

HuLPr27507

PHOSPHORYLATION

1874

S

PhosphoSitePlus

13831261

LTP

N

HuLPr27507

PHOSPHORYLATION

1876

T

PhosphoSitePlus

13831264

LTP

N

HuLPr27507

PHOSPHORYLATION

1880

Y

PhosphoSitePlus

13831267

LTP

N

HuLPr27507

PHOSPHORYLATION

2481

S

PhosphoSitePlus

447498

LTP

N

HuLPr27507

PHOSPHORYLATION

1162

T

PhosphoSitePlus

2525706

HTP

N

HuLPr27507

PHOSPHORYLATION

2448

S

PhosphoSitePlus

447578

LTP

N

HuLPr27507

PHOSPHORYLATION

2446

T

PhosphoSitePlus

450853

LTP

N

Pathway

Pathway name

CDC42_signaling_events

Pathway name

CXCR3-mediated_signaling_events

Pathway name

CXCR4-mediated_signaling_events

Pathway name

ErbB1_downstream_signaling

Pathway name

ErbB2/ErbB3_signaling_events

Pathway name

EGFR-dependent_Endothelin_signaling_events

Pathway name

IFN-gamma_pathway

Pathway name

IL12-mediated_signaling_events

Pathway name

IL2_signaling_events_mediated_by_PI3K

Pathway name

IL4-mediated_signaling_events

Pathway name

LKB1_signaling_events

Pathway name

Signaling_events_mediated_by_Hepatocyte_Growth_Factor_Receptor_(c-Met)

Pathway name

mTOR_signaling_pathway

Pathway name

Class_I_PI3K_signaling_events_mediated_by_Akt

Pathway name

Regulation_of_Telomerase

Pathway name

Insulin_Signalling