Protein basic information
| LiverAtlas Protein ID |
HuLPr27526 |
|
Uniprot ID |
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Uniprot Acc |
Q8WXI7;Q6ZQW5;Q96RK2; |
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Protein name |
Mucin-16 |
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Comment |
FUNCTION:Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces (By similarity).||SUBUNIT:Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type I membrane protein. Secreted, extracellular space. Note=May be liberated into the extracellular space following the phosphorylation of the intracellular C-terminus which induces the proteolytic cleavage and liberation of the extracellular domain.||TISSUE SPECIFICITY:Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas.||INDUCTION:Up-regulated in ovarian cancer cells.||DOMAIN:Composed of three doma |
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Subcellular localization |
Cell membrane;Single-pass type I membrane protein.Secreted, extracellular space. |
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Gene name |
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Protein sequence
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MLKPSGLPGSSSPTRSLMTGSRSTKATPEMDSGLTGATLS PKTSTGAIVVTEHTLPFTSPDKTLASPTSSVVGRTTQSL GVMSSALPESTSRGMTHSEQRTSPSLSPQVNGTPSRNYP ATSMVSGLSSPRTRTSSTEGNFTKEASTYTLTVETTSGP VTEKYTVPTETSTTEGDSTETPWDTRYIPVKITSPMKTF ADSTASKENAPVSMTPAETTVTDSHTPGRTNPSFGTLYS SFLDLSPKGTPNSRGETSLELILSTTGYPFSSPEPGSAG HSRISTSAPLSSSASVLDNKISETSIFSGQSLTSPLSPG VPEARASTMPNSAIPFSMTLSNAETSAERVRSTISSLGT PSISTKQTAETILTFHAFAETMDIPSTHIAKTLASEWLG SPGTLGGTSTSALTTTSPSTTLVSEETNTHHSTSGKETE GTLNTSMTPLETSAPGEESEMTATLVPTLGFTTLDSKIR SPSQVSSSHPTRELRTTGSTSGRQSSSTAAHGSSDILRA TTSSTSKASSWTSESTAQQFSEPQHTQWVETSPSMKTER PPASTSVAAPITTSVPSVVSGFTTLKTSSTKGIWLEETS ADTLIGESTAGPTTHQFAVPTGISMTGGSSTRGSQGTTH LLTRATASSETSADLTLATNGVPVSVSPAVSKTAAGSSP PGGTKPSYTMVSSVIPETSSLQSSAFREGTSLGLTPLNT RHPFSSPEPDSAGHTKISTSIPLLSSASVLEDKVSATST FSHHKATSSITTGTPEISTKTKPSSAVLSSMTLSNAATS PERVRNATSPLTHPSPSGEETAGSVLTLSTSAETTDSPN IHPTGTLTSESSESPSTLSLPSVSGVKTTFSSSTPSTHL FTSGEETEETSNPSVSQPETSVSRVRTTLASTSVPTPVF PTMDTWPTRSAQFSSSHLVSELRATSSTSVTNSTGSALP KISHLTGTATMSQTNRDTFNDSAAPQSTTWPETSPRFKT GLPSATTTVSTSATSLSATVMVSK |
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Database cross reference |
RefSeq Protein accession:NP_078966
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Liver relevance
|
HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005615;C:extracellular space;IEA:UniProtKB-SubCell. GO:0019898;C:extrinsic to membrane;IDA:UniProtKB. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell. |
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GO-F |
GO:0005515;F:protein binding;IPI:UniProtKB. |
|
GO-P |
GO:0007155;P:cell adhesion;NAS:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr27526 |
PHOSPHORYLATION |
12486 |
T |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
12642 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
12781 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
12797 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
12937 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
12953 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
15747 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
15763 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
15902 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
15918 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
16213 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
16229 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
16697 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
12262 |
S |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
14447 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
10572 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
10778 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
10796 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
10806 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
955 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27526 |
PHOSPHORYLATION |
959 |
S |
PhosphoSitePlus |
LTP |
N |
|
