HuLPr27535

Uniprot ID

MUC4_HUMAN

Uniprot Acc

Q99102;O95938;Q9GZM2;Q9GZV6;Q9H481;Q9H482;Q9H483;Q9H484;Q9H485;Q9H486;Q9H487;Q9H4D6;Q9H4D8;Q9NPJ0;Q9NY09;Q9NY75;Q9NY76;Q9NY77;Q9NY78;Q9NY79;Q9NY80;Q9NY81;

Protein name

Mucin-4

Comment

FUNCTION:May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation.||SUBUNIT:A heterodimeric complex, composed of a mucin-4 alpha chain

Subcellular localization

Membrane;Single-pass membrane protein(Potential).Secreted.

Gene name

mucin 4, cell surface associated

Protein sequence

MKGARWRRVPWVSLSCLCLCLLPHVVPGTTEDTLITGSKT PAPVTSTGSTTATLEGQSTAASSRTSNQDISASSQNHQT KSTETTSKAQTDTLTQMMTSTLFSSPSVHNVMETVTQET APPDEMTTSFPSSVTNTLMMTSKTITMTTSTDSTLGNTE ETSTAGTESSTPVTSAVSITAGQEGQSRTTSWRTSIQDT SASSQNHWTRSTQTTRESQTSTLTHRTTSTPSFSPSVHN VTGTVSQKTSPSGETATSSLCSVTNTSMMTSEKITVTTS TGSTLGNPGETSSVPVTGSLMPVTSAALVTVDPEGQSPA TFSRTSTQDTTAFSKNHQTQSVETTRVSQINTLNTLTPV TTSTVLSSPSGFNPSGTVSQETFPSGETTISSPSSVSNT FLVTSKVFRMPISRDSTLGNTEETSLSVSGTISAITSKV STIWWSDTLSTALSPSSLPPKISTAFHTQQSEGAETTGR PHERSSFSPGVSQEIFTLHETTTWPSSFSSKGHTTWSQT ELPSTSTGAATRLVTGNPSTRAAGTIPRVPSKVSAIGEP GEPTTYSSHSTTLPKTTGAGAQTQWTQETGTTGEALLSS PSYSVIQMIKTATSPSSSPMLDRHTSQQITTAPSTNHST IHSTSTSPQESPAVSQRGHTRAPQTTQESQTTRSVSPMT DTKTVTTPGSSFTASGHSPSEIVPQDAPTISAATTFAPA PTGNGHTTQAPTTALQAAPSSHDATLGPSGGTSLSKTGA LTLANSVVSTPGGPEGQWTSASASTSPDTAAAMTHTHQA ESTEASGQTQTSEPASSGSRTTSAGTATPSSSGASGTTP SGSEGISTSGETTRFSSNPSRDSHTTQSTTELLSASASH GAIPVSTGMASSIVPGTFHPTLSEASTAGRPTGQSSPTS PSASPQETAAISRMAQTQRTGTSRGSDTISLASQATDTF STVPPTPPSITSSGLTSPQTQTHTLSPSGSGKTFTTALI SNATPLPVTSTSSASTGHATPLAV

Database cross reference

RefSeq Protein accession:NP_004523
RefSeq Protein gi:112382233

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005887;C:integral to plasma membrane;TAS:ProtInc. GO:0005578;C:proteinaceous extracellular matrix;NAS:UniProtKB.

GO-F

GO:0005176;F:ErbB-2 class receptor binding;TAS:ProtInc. GO:0030197;F:extracellular matrix constituent, lubricant activity;NAS:UniProtKB.

GO-P

GO:0007160;P:cell-matrix adhesion;IEA:InterPro.