HuLPr27536

Uniprot ID

MUC5A_HUMAN

Uniprot Acc

P98088;O60460;O76065;Q13792;Q14425;Q658Q1;Q7M4S5;Q8N4M9;Q8WWQ3;Q8WWQ4;Q8WWQ5;

Protein name

Mucin-5AC

Comment

FUNCTION:Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particules that are subsequently removed by the mucocilary system.||SUBUNIT:Multimeric. Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD).||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:Highly expressed in surface mucosal cells of respiratory tract and stomach epithelia. Overexpressed in a number of carcinomas. Also expressed in Barrett's esophagus epithelium and in the proximal duodenum.||DOMAIN:The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.||PTM:C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser- rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis.||

Subcellular localization

Secreted.

Gene name

mucin 5AC, oligomeric mucus/gel-forming

Protein sequence

MSVGRRKLALLWALALALACTRHTGHAQDGSSESSYKHHP ALSPIARGPSGVPLRGATVFPSLRTIPVVRASNPAHNGR VCSTWGSFHYKTFDGDVFRFPGLCNYVFSEHCGAAYEDF NIQLRRSQESAAPTLSRVLMKVDGVVIQLTKGSVLVNGH PVLLPFSQSGVLIQQSSSYTKVEARLGLVLMWNHDDSLL LELDTKYANKTCGLCGDFNGMPVVSELLSHNTKLTPMEF GNLQKMDDPTEQCQDPVPEPPRNCSTGFGICEELLHGQL FSGCVALVDVGSYLEACRQDLCFCEDTDLLSCVCHTLAE YSRQCTHAGGLPQDWRGPDFCPQKCPNNMQYHECRSPCA DTCSNQEHSRACEDHCVAGCFCPEGTVLDDIGQTGCVPV SKCACVYNGAAYAPGATYSTDCTNCTCSGGRWSCQEVPC PDTCSVLGGAHFSTFDGKQYTVHGDCSYVLTKPCDSSAF TVLAELRRCGLTDSETCLKSVTLSLDGAQTVVVIKASGE VFLNQIYTQLPISAANVTIFRPSTFFIIAQTSLGLQLNL QPVPTMQLFMQLAPKLRGQTCGLCGNFNSIQADDFRTLS GVVEATAAAFFNTFKTQAACPNIRNSFEDPCSLSVENEK YAQHWCSQLTDADGPFGRCHAAVKPGTYYSNCVFDTCNC ERSEDCLCAALSSYVHACAAKGVQLGGWRDGVCTKPMTT CPKSMTYHYHVSTCQPTCRSLSEGDITCSVGFIPVDGCI CPKGTFLDDTGKCVQASNCPCYHRGSMIPNGESVHDSGA ICTCTHGKLSCIGGQAPAPVCAAPMVFFDCRNATPGDTG AGCQKSCHTLDMTCYSPQCVPGCVCPDGLVADGEGGCIT AEDCPCVHNEASYRAGQTIRVGCNTCTCDSRMWRCTDDP CLATCAVYGDGHYLTFDGQSYSFNGDCEYTLVQNHCGGK DSTQDSFRVVTENVPCGTTGTTCSKAIKIFLGGFELKLS HGKVEVIGTDESQEVPYTIQQMGI

Database cross reference

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0043205;C:fibril;IDA:MGI.

GO-F

GO:0005201;F:extracellular matrix structural constituent;TAS:UniProtKB.

GO-P

GO:0007155;P:cell adhesion;NAS:UniProtKB. GO:0007586;P:digestion;NAS:UniProtKB. GO:0043206;P:fibril organization;IDA:MGI.

IL2

IL6

IL9

Leptin