Protein basic information
| LiverAtlas Protein ID |
HuLPr27556 |
|
Uniprot ID |
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Uniprot Acc |
P53602;Q53Y65; |
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Protein name |
Diphosphomevalonate decarboxylase |
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Comment |
FUNCTION:Performs the first committed step in the biosynthesis of isoprenes.||CATALYTIC ACTIVITY:ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2).||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=7.4 uM for (R)-5-diphosphomevalonate; KM=0.32 mM for ATP;||PATHWAY:Steroid biosynthesis; cholesterol biosynthesis.||SUBUNIT:Homodimer.||TISSUE SPECIFICITY:Expressed in heart, skeletal muscle, lung, liver, brain, pancreas, kidney and placenta.||SIMILARITY:Belongs to the diphosphomevalonate decarboxylase family. |
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Gene name |
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Protein sequence
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MASEKPLAAVTCTAPVNIAVIKYWGKRDEELVLPINSSLS VTLHQDQLKTTTTAVISKDFTEDRIWLNGREEDVGQPRL QACLREIRCLARKRRNSRDGDPLPSSLSCKVHVASVNNF PTAAGLASSAAGYACLAYTLARVYGVESDLSEVARRGSG SACRSLYGGFVEWQMGEQADGKDSIARQVAPESHWPELR VLILVVSAEKKLTGSTVGMRASVETSPLLRFRAESVVPA RMAEMARCIRERDFPSFAQLTMKDSNQFHATCLDTFPPI SYLNAISWRIIHLVHRFNAHHGDTKVAYTFDAGPNAVIF TLDDTVAEFVAAVWHGFPPGSNGDTFLKGLQVRPAPLSA ELQAALAMEPTPGGVKYIIVTQVGPGPQILDDPCAHLLG PDGLPKPAA |
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Database cross reference |
RefSeq Protein accession:NP_002452
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005829;C:cytosol;IDA:UniProtKB. |
|
GO-F |
GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0004163;F:diphosphomevalonate decarboxylase activity;IDA:UniProtKB. GO:0030544;F:Hsp70 protein binding;IPI:UniProtKB. GO:0016301;F:kinase activity;IEA:InterPro. GO:0042803;F:protein homodimerization activit |
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GO-P |
GO:0006695;P:cholesterol biosynthetic process;NAS:UniProtKB. GO:0008284;P:positive regulation of cell proliferation;IMP:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr27556 |
PHOSPHORYLATION |
96 |
S |
Phospho-ELM |
HTP |
yes |
 
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|
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HuLPr27556 |
PHOSPHORYLATION |
221 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27556 |
PHOSPHORYLATION |
209 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27556 |
PHOSPHORYLATION |
211 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27556 |
PHOSPHORYLATION |
212 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27556 |
PHOSPHORYLATION |
222 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr27556 |
PHOSPHORYLATION |
96 |
S |
PhosphoSitePlus |
LTP |
yes |
|
|
|
HuLPr27556 |
PHOSPHORYLATION |
50 |
T |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name |
