Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr27670

Uniprot ID

N2DL1_HUMAN

Uniprot Acc

Q9BZM6;Q8IZW3;Q8IZX6;

Protein name

NKG2D ligand 1

Comment

FUNCTION:Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP1 to be retained in the ER and cis- Golgi apparatus so that it does not reach the cell surface.||SUBUNIT:Interacts with the CMV glycoprotein UL16. Does not bind to beta2-microglobulin.||SUBCELLULAR LOCATION:Cell membrane; Lipid-anchor, GPI-anchor. Endoplasmic reticulum. Note=Detected intracellularly in the endoplasmic reticulum of CMV-infected fibroblasts.||TISSUE SPECIFICITY:Expressed in T-cells,

Subcellular localization

Cell membrane;Lipid-anchor, GPI-anchor.Endoplasmic reticulum.

Gene name

UL16 binding protein 1

Protein sequence

MAAAASPAFLLCLPLLHLLSGWSRAGWVDTHCLCYDFIIT PKSRPEPQWCEVQGLVDERPFLHYDCVNHKAKAFASLGK KVNVTKTWEEQTETLRDVVDFLKGQLLDIQVENLIPIEP LTLQARMSCEHEAHGHGRGSWQFLFNGQKFLLFDSNNRK WTALHPGAKKMTEKWEKNRDVTMFFQKISLGDCKMWLEE FLMYWEQMLDPTKPPSLAPGTTQPKAMATTLSPWSLLII FLCFILAGR

Database cross reference

RefSeq Protein accession:NP_079494
RefSeq Protein gi:13376826

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0031225;C:anchored to membrane;IEA:UniProtKB-KW. GO:0005783;C:endoplasmic reticulum;IEA:UniProtKB-SubCell. GO:0042612;C:MHC class I protein complex;IEA:InterPro.

GO-F

GO:0032393;F:MHC class I receptor activity;NAS:UniProtKB.

GO-P

GO:0019882;P:antigen processing and presentation;IEA:InterPro. GO:0006955;P:immune response;IEA:InterPro. GO:0030101;P:natural killer cell activation;NAS:UniProtKB. GO:0050776;P:regulation of immune response;TAS:Reactome.